PROVIDES A TIMELY UPDATE TO A KEY TEXTBOOK ON HUMAN DRUG METABOLISM
The third edition of this comprehensive book covers basic concepts of
teaching drug metabolism, starting from extreme clinical consequences
to systems and mechanisms and toxicity. It provides an invaluable
introduction to the core areas of pharmacology and examines recent
progress and advances in this fast moving field and its clinical
impact.
_Human Drug Metabolism, 3rd Edition_ begins by covering basic concepts
such as clearance and bioavailability, and looks at the evolution of
biotransformation, and how drugs fit into this carefully managed
biological environment. More information on how cytochrome P450s
function and how they are modulated at the sub-cellular level is
offered in this new edition. The book also introduces helpful concepts
for those struggling with the relationship of pharmacology to
physiology, as well as the inhibition of biotransformational activity.
Recent advances in knowledge of a number of other metabolizing systems
are covered, including glucuronidation and sulphation, along with the
main drug transporters. Also, themes from the last edition are
developed in an attempt to chart the progress of personalized medicine
from concepts towards practical inclusion in routine therapeutics. The
last chapter focuses on our understanding of how and why drugs injure
us, both in predictable and unpredictable ways. Appendix A highlights
some practical approaches employed in both drug metabolism research
and drug discovery, whilst Appendix B outlines the metabolism of some
drugs of abuse. Appendix C advises on formal examination preparation
and Appendix D lists some substrates, inducers and inhibitors of the
major human cytochrome P450s.
* Fully updated to reflect advances in the scientific field of drug
metabolism and its clinical impact
* Reflects refinements in the author's teaching method, particularly
with respect to helping students understand biological systems and how
they operate
* Illustrates the growing relationship between drug metabolism and
personalized medicine
* Includes recent developments in drug discovery, genomics, and stem
cell technologies
_Human Drug Metabolism, 3rd Edition_ is an excellent book for advanced
undergraduate and graduate students in molecular biology,
biochemistry, pharmacology, pharmacy, and toxicology. It will also
appeal to professionals interested in an introduction to this field,
or who want to learn more about these bench-to-bedside topics to apply
it to their practice.
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Produktdetaljer
ISBN
9781119458616
Publisert
2019
Utgave
3. utgave
Utgiver
Vendor
Wiley-Blackwell
Språk
Product language
Engelsk
Format
Product format
Digital bok
Forfatter