For drugs with a narrow therapeutic index, therapeutic drug monitoring methods are essential for patient management. Providing practical guidelines for implementing chromatographic methods, this title describes the theory and application of therapeutic drug monitoring in clinical laboratories.

Introduction to Therapeutic Drug Monitoring and Chromatography. Preanalytical Variables and Therapeutic Drug Monitoring. Immunoassays for Therapeutic Drug Monitoring: Pitfalls and Limitations. Introduction to Tandem Mass Spectrometry. Analytical Support of Classical Anticonvulsant Drug Monitoring beyond Immunoassay: Application of Chromatographic Methods. Clinical Practice of Therapeutic Drug Monitoring of New Anticonvulsants. Chromatographic Techniques in the Therapeutic Drug Monitoring of New Anticonvulsants.Problems with Digoxin Immunoassays. Liquid Chromatography Combined with Immunoassay as a Reference Method for Analysis of Digitalis. Chromatographic Methods for Analysis of Cardioactive Drugs. Immunoassays for Tricyclic Antidepressants: Unsuitable for Therapeutic Drug Monitoring? Chromatographic Techniques for the Analysis of Antidepressants. Pharmacokinetics and Therapeutic Drug Monitoring of Immunosuppressants. Analysis of Immunosuppressants by Liquid Chromatography or Liquid Chromatography with Mass Spectrometry. Therapeutic Drug Monitoring in Cancer Patients: Application of Chromatographic Techniques. Therapeutic Drug Monitoring of Vancomycin and Aminoglycosides with Guidelines. Chromatographic Methods for Analysis of Antibiotics. Need for Therapeutic Drug Monitoring of Antiretroviral Medications in HIV Infection. Chromatographic Techniques for Therapeutic Drug Monitoring of Antiretroviral Drugs. Chromatography in Therapeutic Drug Monitoring of Nonnarcotic Analgesics and Anti-inflammatory Drugs. Therapeutic Drug Monitoring in Pain Management: Application of Chromatography and Mass Spectrometry. Investigation of Drug–herb Interactions: Application of various Chromatographic Techniques for Analysis of Active Components of Herbal Supplements.

…This excellent book reviews not only those drugs for which chromatographic techniques have long been used, but also drugs for which therapeutic monitoring is newer (e.g., antiretroviral agents, immunosuppressive drugs, antineoplastic compounds, antidepressant drugs, analgesics, cardioactive drugs, and antibiotics). … Edited by a distinguished authority on therapeutic drug monitoring, this book should serve as both an invaluable reference for analytical toxicologists and a practical guide for laboratory physicians and scientists who are involved in the monitoring of therapeutic agents.—From the Foreword, David N. Bailey, Vice Chancellor for Health Affairs, Dean of the School of Medicine, and Professor of Pathology & Laboratory Medicine, University of California, Irvine, USA… a valuable reference for experienced clinical laboratory professionals, as well as an opportunity to inform a new generation of scientists and clinicians of the future potential and growing importance of clinical TDM.—Michael Hodsdon in Future Science, May 2010, vol. 2, no. 5