CONTENTS1. The Biology and Genetics of Cells and Organisms 2. The Nature of Cancer 3. Tumor Viruses 4. Cellular Oncogenes5. Growth Factors, Receptors, and Cancer 6. Cytoplasmic Signaling Circuitry Programs Many of the Traits of Cancer 7. Tumor Suppressor Genes 8. pRb and Control of the Cell Cycle Clock 9. p53 and Apoptosis: Master Guardian and Executioner10. Eternal Life: Cell Immortalization and Tumorigenesis 11. Multi-step Tumorigenesis 12. Maintenance of Genomic Integrity and the Development of Cancer 13. Dialogue Replaces Monologue: Heterotypic Interactions and the Biology of Angiogenesis14. Moving Out: Invasion and Metastasis 15. Crowd Control: Tumor Immunology and Immunotherapy 16. The Rational Treatment of Cancer

"The book fulfills its purpose and is, indeed, a must-read for students of cancer biology…It includes updated information and concepts in cancer research that justify replacing the previous edition."- Doody Reviews "This publication represents an exhaustive and detailed coverage of the field of basic oncology oriented toward a student audience, and it continues to set the highest example of excellence in the field of undergraduate and graduate oncology." - The Quarterly Review of Biology "Clearly, not only is it an authoritative text book on the complex biology of cancer, it serves as an invaluable reference document for individuals working in biomedical laboratories as well as professionals involved in day to day management of cancer in the clinics." - Oncology News Praise for the First Edition of THE BIOLOGY OF CANCER by Robert A. Weinberg: “There is no comparable text in cancer biology…”- Nature “The Biology of Cancer is no doubt the definitive statement on its topic today.”- Science “Here, at last, we have a definitive textbook specifically devoted to the molecular and cell biology of cancer.”- Bioscience Education “Overall, this is a remarkable achievement that is by far the most comprehensive coverage of this field available.”- Times Higher Education Supplement

AN IN-DEPTH, RESEARCH-FOCUSED PRESENTATION OF THE SCIENCE This text is written by one of the preeminent cancer biologists of the last 40 years. The information within unfolds through the presentation of key experiments. This gives readers a sense of discovery while providing insights into the conceptual foundation of modern cancer biology. AN EXTENSIVE, DETAILED ART PROGRAMME PROMOTES DEEP CONCEPTUAL UNDERSTANDING Research data, by its very nature, is a visual medium. The art programme emphasises this fact to help readers truly understand key principles. Full-colour figures present the latest research in vibrant and precise detail. These figures are accompanied by equally detailed figure captions. PREPARES STUDENTS TO READ PRIMARY-RESEARCH ARTICLES Cancer biology is a rapidly advancing field, with new discoveries constantly appearing in the primary literature. The text combines a research-oriented approach with a clear, engaging narrative. These elements work together to help students read and interpret data-based information. Additional features further prepare students to read primary-research literature.