Available for the first time in paperback, The Bipolar Book presents a stimulating discussion of the most current research on the neurobiology, characteristics, and treatment of this highly complex disorder.

Section I: Clinical Presentation Chapter 1. From the Era of Aretaeus to the Millennium: History of Bipolar Disorder Over 2000 Years Chapter 2. Update on Epidemiology, Risk Factors and Correlates of Bipolar Spectrum Disorder Chapter 3. Clinical Presentation & DSM-based Diagnostic Assessment Chapter 4. Differential Diagnosis & Bipolar Spectrum Disorders Chapter 5. Diagnosing Bipolar Disorder in Children and Adolescents Chapter 6. Effect of Public Awareness & Stigmatization on Accurate & Timely Diagnosis of Bipolar Disorder Section II: Insights on Pathophysiology & Future Treatments Part I: Molecular Biology Chapter 7. Oxidative Damage & Its Treatment Impact Chapter 8. The Role of Signal Transduction Systems in the Pathophysiology and Treatment of Bipolar Disorder Chapter 9. Cellular Resilience and Neurodegeneration and Their Impact on the Treatment of Bipolar Disorder Chapter 10. Immune Mechanisms and Inflammation & Their Treatment Impact Chapter 11. Circadian Rhythms and Sleep & Its Treatment Impact Chapter 12. HPA & HPT Axis & Their Treatment Impact Chapter 13. Translating Bio-markers and Bio-molecular Treatments to Clinical Practice: Assessment of Hypothesis Driven Clinical Trial Data Part II: Genetic Chapter 14. Bipolar Family & Bipolar Offspring Studies: Any Clues for Prevention or Early Intervention Chapter 15. The Emerging Genetics of Bipolar Disorder Part III: Cognition Chapter 16: Cognitive Impairments and Everyday Disability in Bipolar Illness Part IV: Neuroimaging Chapter 17. Structural & Functional Magnetic Resonance Imaging Findings & Their Treatment Impact Chapter 18. Magnetic Resonance Spectroscopy Findings & Their Treatment Impact Chapter 19. PET Scan Findings & Their Treatment Impact Part V: Postmortem studies Chapter 20. Postmortem Findings in Bipolar Disorder & Their Treatment Impact Section III: Current Treatments Part I: Pharmacological Treatments Chapter 21. Treatment of Mania & Mixed States Chapter 22. Pharmacological Treatment of Acute Bipolar Depression Chapter 23. Maintenance Treatments in Bipolar Disorder Chapter 24. Importance of Early Intervention in Bipolar Disorder Chapter 25. Alternative and Complementary Treatments Part II: Somatic Non-Pharmacological Treatments Chapter 26. ECT and Bipolar Disorder Chapter 27. Neuromodulative Treatments for Bipolar Disorder: Repetitive Transcranial Magnetic Stimulation, Vagus Nerve Stimulation and Deep Brain Stimulation Part III: Adverse treatment effects Chapter 28. Management of Metabolic and Endocrinological Effects Chapter 29. Neurological, Cognitive and Neuroprotective Effects of Treatments in Bipolar Disorder Chapter 30. Treatment Induced Mood Instability-TEAs and Cycle Acceleration Part IV: Psychotherapy Chapter 31. Cognitive Behavioral Therapy and Psychoeducation Chapter 32. Family Focused Therapy, Interpersonal and Social Rhythm Therapy & Dialectical Behavioral Therapy Part V: Comorbidity Chapter 33. Management of Comorbid Axis-I Psychiatric Disorders Chapter 34. Management of Cyclothymia and Comorbid Axis-II Psychiatric Disorders Chapter 35. Management of Comorbid Substance or Alcohol Abuse Chapter 36. Management of Comorbid Medical Problems Part VI: Suicidality Chapter 37. Clinical Management of Suicide Risk Part VII: Pregnancy & Lactation Chapter 38. Management of Bipolar Disorder During Pregnancy and Lactation Part VIII: Children & Adolescents Chapter 39. Management of Bipolar Disorder in Children and Adolescents Part IX: Elderly Chapter 40. Bipolar Disorder in the Elderly Section IV: Future Research Chapter 41. Placebo Response in Clinical Trials for Bipolar Disorder: Potential Causes, Potential Solutions Chapter 42. Strategies for Improving Randomized Trial Evidence in Treatment of Bipolar Disorder Chapter 43. Challenges in Designing Reliable and Feasible Treatment Trials for Bipolar Disorder Chapter 44. Sequential Multiple Assignment Randomized Trials Chapter 45. Traditional and Novel Research Synthesis Approaches to Support Evidence-based Treatment Decisions

Selling point: Available for the first time in paperback Selling point: Highlights emphasis on the molecular aspects of bipolar disorder Selling point: Features clinical trials and alternative treatments of bipolar disorder Selling point: Contextualizes the historical beginnings of bipolar disorder up to the present-day Selling point: Provides information on diagnosis and treatment of bipolar disorder in special populations, including children, the elderly, and pregnant or breast-feeding women

Aysegül Yildiz, MD Professor of Psychiatry Dokuz Eylül University Izmir, Turkey Pedro Ruiz, MD Clinical Professor of Psychiatry and Behavioral Sciences University of Texas Medical School at Houston Houston, TX, USA Charles B. Nemeroff, MD, PhD Leonard M. Miller Professor & Chairman Department of Psychiatry University of Miami - Miller School of Medicine Miami, FL, USA

Selling point: Available for the first time in paperback Selling point: Highlights emphasis on the molecular aspects of bipolar disorder Selling point: Features clinical trials and alternative treatments of bipolar disorder Selling point: Contextualizes the historical beginnings of bipolar disorder up to the present-day Selling point: Provides information on diagnosis and treatment of bipolar disorder in special populations, including children, the elderly, and pregnant or breast-feeding women