Preface ix Acknowedgements xi Abbreviations xiii 1 The Modern Management of Cancer: An Introductory Note 1 2 Epidemiology, Cure, Treatment Trials and Screening 7 3 Biology of Cancer 25 4 Staging of Tumours 44 5 Radiotherapy 60 6 Systemic Treatment for Cancer 81 7 Supportive Care and Symptom Relief 113 8 Medical Problems and Radiotherapy Emergencies 130 9 Paraneoplastic Syndromes 148 10 Cancer of the Head and Neck 158 11 Brain and Spinal Cord 184 12 Tumours of the Lung and Mediastinum 209 13 Breast Cancer 237 14 Cancer of the Oesophagus and Stomach 275 15 Cancer of the Liver, Biliary Tract and Pancreas 290 16 Tumours of the Small and Large Bowel 308 17 Gynaecological Cancer 321 18 Genitourinary Cancer 355 19 Testicular Cancer 388 20 Thyroid and Adrenal Cancer 406 21 Cancer from an Unknown Primary Site 421 22 Skin Cancer 426 23 Bone and Soft-Tissue Sarcomas 446 24 Paediatric Malignancies 470 25 Hodgkin’s Lymphoma 497 26 Non-Hodgkin’s Lymphomas 516 27 Myeloma and Other Paraproteinaemias 545 28 Leukaemia 560 Index 585

Now in its seventh edition, this highly-regarded book is designed as an introductory and reference text on the principles of diagnosis, staging, and treatment of tumours. Oncology is a very rapidly changing specialty, and for the cancer physician and allied healthcare staff, keeping abreast of clinical and research advances and the impact they will have on day-to-day patient management can be extremely challenging. As with previous editions, the aim of Cancer and its Management is to provide a thorough yet reasonably brief account of the whole field of oncology, focusing on the latest principles of cancer management. The first part of the book is devoted to the mechanisms of tumour development and cancer treatment. This is followed by a systematic account of the current management of individual major cancers. For each tumour site, the authors supply details of the pathology, mode of spread, clinical presentation and staging, together with an overview of available treatment strategies including radiotherapy, chemotherapy, and surgery.                                       Accessible and practical, this resource will be invaluable to trainees and specialists in oncology, palliative care and general medicine, as well as specialist nurses, general practitioners, medical students, and the many professions allied to medicine. The Seventh edition: Includes up-to-date information on the most recent techniques and therapies available,Emphasises the importance of multidisciplinary teamwork in the care of cancer patients,Highlights frequent dilemmas and difficulties encountered during cancer management,Discusses controversial topics including screening, genetic testing, prevention and AIDS-related cancers,New colour design and figures.