The much-anticipated 3rd edition of Cell Biology delivers comprehensive, clearly written, and richly illustrated content to today's students, all in a user-friendly format. Relevant to both research and clinical practice, this rich resource covers key principles of cellular function and uses them to explain how molecular defects lead to cellular dysfunction and cause human disease. Concise text and visually amazing graphics simplify complex information and help readers make the most of their study time. Clearly written format incorporates rich illustrations, diagrams, and charts. Uses real examples to illustrate key cell biology concepts. Includes beneficial cell physiology coverage. Clinically oriented text relates cell biology to pathophysiology and medicine. Takes a mechanistic approach to molecular processes. Major new didactic chapter flow leads with the latest on genome organization, gene expression and RNA processing. Boasts exciting new content including the evolutionary origin of eukaryotes, super resolution fluorescence microscopy, cryo-electron microscopy, gene editing by CRISPR/Cas9, contributions of high throughput DNA sequencing to understand genome organization and gene expression, microRNAs, IncRNAs, membrane-shaping proteins, organelle-organelle contact sites, microbiota, autophagy, ERAD, motor protein mechanisms, stem cells, and cell cycle regulation. Features specially expanded coverage of genome sequencing and regulation, endocytosis, cancer genomics, the cytoskeleton, DNA damage response, necroptosis, and RNA processing. Includes hundreds of new and updated diagrams and micrographs,plus fifty new protein and RNA structures to explain molecular mechanisms in unprecedented detail. Student Consult eBook version included with purchase. This enhanced eBook experience allows you to search all of the text, figures, images, and over a dozen animations from the book on a variety of devices.
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Section 1: Introduction to Cell Biology 1 Introduction to Cells 2 Evolution of Life on Earth Section 2: Chemical and Physical Background 3 Molecules: Structures and Dynamics 4 Biophysical Principles 5 Macromolecular Assembly 6 Research Strategies Section 3: Chromatin, Chromosomes, and the Cell Nucleus 7 Chromosome Organization 8 DNA Packaging in Chromatin and Chromosomes 9 Nuclear Structure and Dynamics Section 4: Central Dogma: From Gene to Protein 10 Gene Expression 11 Eukaryotic RNA Processing 12 Protein Synthesis and Folding Section 5: Membrane Structure and Function 13 Membrane Structure and Dynamics 14 Membrane Pumps 15  Membrane Carriers 16 Membrane Channels 17 Membrane Physiology Section 6: Cellular Organelles and Membrane Trafficking 18 Posttranslational Targeting of Proteins 19 Mitochondria, Chloroplasts, Peroxisomes 20 Endoplasmic Reticulum 21 Secretory Membrane System and Golgi Apparatus 22 Endocytosis and the Endosomal Membrane 23 Processing and Degradation of Cellular Components Section 7: Signaling Mechanisms 24 Plasma Membrane Receptors 25 Protein Hardware for Signaling 26 Second Messengers 27 Integration of Signals Section 8: Cellular Adhesion and the Extracellular Matrix 28 Cells of the Extracellular Matrix and Immune System 29 Extracellular Matrix Molecules 30 Cellular Adhesion 31 Intercellular Junctions 32 Connective Tissues Section 9: Cytoskeleton and Cellular Motility 33 Actin and Actin-Binding Proteins 34 Microtubules and Centrosomes 35 Intermediate Filaments 36 Motor Proteins 37 Intracellular Motility 38 Cellular Motility 39 Muscles Section 10: Cell Cycle 40 Introduction to the Cell Cycle 41 G1 Phase and Regulation of Cell Proliferation 42 S Phase and DNA Replication 43 G2 Phase and Control of Entry into Mitosis 44 Mitosis and Cytokinesis 45 Meiosis 46 Programmed Cell Death Glossary Appendix
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Produktdetaljer

ISBN
9780323341264
Publisert
2017-01-05
Utgave
3. utgave
Utgiver
Vendor
Elsevier - Health Sciences Division
Vekt
2020 gr
Høyde
276 mm
Bredde
216 mm
Aldersnivå
U, 05
Språk
Product language
Engelsk
Format
Product format
Innbundet
Antall sider
908

Biographical note

Thomas Dean Pollard is a prominent educator, cell biologist and biophysicist whose research focuses on understanding cell motility through the study of actin filaments and myosin motors. He is Sterling Professor of Molecular, Cellular & Developmental Biology and a Professor of Cell Biology and Molecular Biophysics & Biochemistry at Yale University. He was Dean of Yale's Graduate School of Arts and Sciences from 2010 to 2014, and President of the Salk Institute for Biological Studies from 1996 to 2001. Pollard is very active in promoting scientific education and research primarily through two major societies, both of which he is a past President: the American Society for Cell Biology and the Biophysical Society William Charles Earnshaw is Professor of Chromosome Dynamics at the University of Edinburgh where he has been a Wellcome Trust Principal Research Fellow since 1996. Earnshaw is an elected Fellow of the Royal Society since 2013 for his studies of mitotic chromosome structure and segregation. Before Edinburgh, he was Professor of Cell Biology and Anatomy at Johns Hopkins School of Medicine. Jennifer Lippincott-Swartz is Group Leader at the Howard Hughes Medical Institute Janelia Research Campus. Her lab uses live cell imaging approaches to analyze the spatio-temporal behaviour and dynamic interactions of molecules in cells with a special focus on neurobiology. Before Janelia, Lippincott-Swartz was a primary investigator and chief of the Section on Organelle Biology in the Cell Biology and Metabolism Branch. Her work there included a collaboration with physicists Eric Betzig and Harald Hess (now group leaders at Janelia), who proposed a new function for the photoactivatable protein. The scientists used the protein to generate photoactivatable fluorophores, or dyes, which enabled them to illuminate different sets of molecules sequentially, creating a microscope image far more detailed than previously possible. The method, called super-resolution microscopy, garnered Betzig the 2014 Nobel Prize in Chemistry. Graham Johnson is a computational biologist and Certified Medical Illustrator (CMI) with approx. 20 years of professional experience. He is Director of the Animated Cell at the Allen Institute. Before the Allen Institute, Johnson's lab in the California Institute for Quantitative Biosciences at the University of California, San Francisco worked to generate, simulate and visualize molecular models of cells. His lab's Mesoscope project and his team at Allen Institute continue this mission by uniting biologists, programmers and artists to interoperate the computational tools of science and art.