A key goal in the treatment of cancer is to achieve selective and
efficient killing of tumor cells. The aim of Cell Death Signaling in
Cancer Biology and Treatment is to describe state-of-the-art
approaches and future opportunities for achieving this goal by
targeting mechanisms and pathways that regulate cancer cell death. In
this book, molecular defects in cell death signaling that characterize
cancer cells, including dysregulation of cell death due to
overexpression/hyperactivation of oncoproteins, as well as the loss of
tumor suppressor proteins will be described. The potential for
targeting microRNAs will be discussed. Multiple chapters will describe
preclinical and clinical approaches that are currently being used to
target epigenetic modifications, DNA repair pathways, and protein
chaperones, as a means of provoking tumor cell death. Finally, the
development and application of novel agents and approaches for
targeting specific components of cell death signaling pathways and
machinery will be reviewed.
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Produktdetaljer
ISBN
9781461458470
Publisert
2019
Utgiver
Vendor
Humana Press
Språk
Product language
Engelsk
Format
Product format
Digital bok