Chromatography is a technique for analyzing or separating mixtures. The first edition of Chromatography: Concepts and Contrasts, published in 1988, was one of the first books to discuss all the different types of chromatography under one cover and is still very popular today.

Preface to Second Edition. Acknowledgments. Preface to the First Edition. Symbols, Abbreviations, and Acronyms. 1 Impact of Industrial and Government Regulatory Practices on Analytical Chromatography. 1.1 Locus of Chromatography in Chemical Industry. 1.2 Governmental Organizations. 1.3 Nongovernmental Agencies. 1.4 Standards, Calibration, and NIST. 1.5 USP and Other Pharmacopoeias. 1.6 International Guidelines for Analytical Laboratories. 1.7 Final Comments. References. 2 Introduction to Chromatography. 2.1 Brief History. 2.2 Definitions and Classifications. 2.3 Summary. References. 3 Band Broadening and Kinetics. 3.1 Configurations of the Stationary Phase. 3.2 Rate Theory. References. 4 Physical Forces and Interactions. 4.1 Intermolecular and Interionic Forces. 4.2 Size Exclusion—Molecular Sieving. 4.3 Some Models. References. 5 Optimization and the Achievement of Separation. 5.1 Kinetics and Zone Broadening. 5.2 Thermodynamics and Zone Migration. 5.2 Achievement of Separation. 5.4 Optimization of Separations. References. 6 Comparisons Between Chromatographic Modes. 6.1 Gas Chromatography Compared to Liquid Chromatography. 6.2 Supercritical Fluids and Supercritical Fluid Chromatography. 6.3 Reduced Parameters. 6.4 Columnar and Planar Configurations. References. 7 Gas Chromatography. 7.1 Early History, Theories, and Classifications. 7.2 Instrumentation for Capillary GC. 7.3 Instrumentation for Packed-Column GC. 7.4 Stationary Phase. 7.5 Temperature Effects. 7.6 Special Topics. 7.7 Summary and Evaluation. References. 8 Liquid Chromatography in Columns. 8.1 Introductory Classifications. 8.2 Classification of HPLC Modes. 8.3 Instrumentation. 8.4 Reversed-Phase Method Development and Optimization. 8.5 RP-HPLC Alternatives for the Pharmaceutical Industry. 8.6 Preparative LC. 8.7 Special Topics. 8.8 Summary and Evaluation. References. 9 Quantitation: Detectors and Methods. 9.1 Detectors. 9.2 Data Acquisition and Processing. 9.3 Quantitative Analysis. References. 10 Chromatography with Mass Spectral Detection (GC/MS and LC/MS). 10.1 Basics of Mass Spectrometry. 10.2 Gas ChromatographyrMass Spectrometry. 10.3 Liquid ChromatographyrMass Spectrometry. 10.4 Other Hyphenated Methods. 10.5 Summary. References. 11 Liquid Chromatography on Plane Surfaces. 11.1 Paper Chromatography. 11.2 Thin-Layer Chromatography. 11.3 Other Topics. 11.4 Literature Summary and Applications. References. 12 Qualitative Analysis. 12.1 Retention Parameters. 12.2 Other Methods of Qualitative Analysis. References. 13 Capillary Electrophoresis and Capillary Electrochromatography 365 13.1 Principles of Electrophoresis. 13.2 Zone Electrophoresis. 13.3 Capillary Electrophoresis. 13.4 Capillary Electrochromatography. References. 14 Sample Preparation. 14.1 Extraction. 14.2 Dialysis. 14.3 Derivatization. References. 15 Special Applications. 15.1 Multidimensional Chromatography. 15.2 Biological Applications. 15.3 Chiral Separations. 15.4 Other Topics. References. 16 Selection of a Method. 16.1 Methods of Attack. 16.2 The Internet. 16.3 Experimental Approach. 16.4 Summary. References. Some Internet Web Sites of Interest to Chromatographers. Appendix A ICH Glossary. Appendix B. Index.

Chromatography: Concepts and Contrasts Covers all chromatographic techniques: GC, HPLC, TLC, SFC, CEC, GC/MS, LC/MS Plus other important separation methods: Liquid-liquid extraction, LLE; solid phase extraction, SPE; single drop microextraction, SDME; Solid phase micro- extraction, SPME; capillary electrophoresis, CE; and capillary zone electrophoresis, CZE Also covers: Multidimensional chromatography, chiral separations, notes on industrial and government practices in regulated industries, and Internet resources A Classic On All Of The Major Chromatographic Techniques—Now Fully Updated Still a popular text today, the first edition of Chromatography: Concepts and Contrasts was one of the first books to cover all of the different types of chromatography. This new Second Edition offers the latest information on the topic while preserving the clear, unified approach that has made the original a classroom favorite. Chromatography: Concepts and Contrasts, Second Edition presents the theoretical base common to various chromatographic methods, giving readers a set of general concepts for a broad understanding of the practice before moving on to discuss specific techniques. It covers gas chromatography (GC), liquid chromatography in columns (LC), and thin layer chromatography (TLC), as well as related topics such as extraction, solid phase extraction, solid phase microextraction, and mass spectrometry. The resulting text combines technical depth and comprehensiveness with accessible language and clear descriptions. New material covered in this Second Edition includes: Sample preparation Capillary electrophoresis and capillary electrochromatography Chromatography with mass spectrometric detection Applications in chemistry, biology, and other areas Industrial and government practices in regulated industries Internet resources for chromatographers Whether used as a graduate or upper-level undergraduate textbook, or as a guide for professionals, Chromatography: Concepts and Contrasts, Second Edition provides the most concise, comprehensive, and up-to-date chromatography resource available today.