The CRC Handbook of Chemistry and Physics, 98th Edition is an update of a classic reference. The 98th Edition contains several new features including, but not limited to - a major update to the table of isotopes, the first major compilation of high quality data of protein-ligand binding thermodynamics, and an important new collection of NMR data critical for understanding outcomes of organic syntheses. Plus, twelve lists have been updated such as, the physical properties of organic compounds and the latest experimental values of bond dissociation energies. Building on the new feature first introduced in the 94th edition, four historical figures in science will be honored on the end plates. The elements - completely revised and updated with a new summary table of key properties Table of the isotopes - a major update to this important data collection with hundreds of new and more accurate data points for more than 3000 isotopes of all the elements Gas clathrates - new data tables for important mixed clathrate systems including methane, ethane, propane, carbon dioxide (new), hydrogen sulfide (new), xenon (new), and nitrogen (new). Ionic liquids - expanded and revised information on over 150 important ionic liquids Protein-ligand binding thermodynamics - the first major compilation of high quality data on these important bio-chemical reactions Common drugs - completely revised with property and functionality data on over 250 drugs 1H chemical shifts of contaminants in deuterated solvents - an important new collection of NMR data critical for understanding outcomes of organic syntheses Electron affinities - new data on over 200 atoms and molecules Atomic and molecular polarizabilities - Updated data value for virtually every element and many important molecules IUPAC guide to nomenclature of inorganic chemistry - this completely revised, four page guide provides easy-to-use access to the nomenclature rules for inorganic compounds Bond dissociation energies - the latest experimental values have been added for a number of molecules Standard Atomic Weights - 2016 changes made by IUPAC Physical properties of organic compounds - results of the first phase of a complete review, with new data of densities Atomic Masses and Abundances - Update of isotopic abundances Periodic Table of the Elements - Updated to include new element names Interstellar Molecules - Complete list of molecules observed in space to date Major World Earthquakes - Updated through 2016 Atmospheric Concentration of CO2 - Updated through 2016 Global Temperature Trend - Updated through 2016 Threshold Limits for Airborne Contaminants - Updated to 2016 recommendations Chemical Carcinogens - Inclusion of 2016 recommendations of National Toxicology Program Nanomaterial Safety Guidelines - Definition of terms in nanoscience; guidelines for safe handling and disposal