With the introduction of antibiotics acute inflammatory disease has ceased to be the dominant problem in general medical practice and its place is now increasingly occupied by chronic inflamma­ tory disease of which the rheumatic diseases constitute the most important group.

Welcome.- Experimental Models of Rheumatoid Lesions.- Experimental Models of Rheumatoid Inflammation. With 4 Figures.- Persistence of Antigen in Experimental Allergic Monoarthritis.- Experimental Subcutaneous Granulomata Simulating R.A. Nodules.- Studies on the Mitotic Responsiveness of “T” Cells After Stimulation with Contact Sensitizing Agents. With 2 Figures.- Rheumatoid-Type Lymph Node Changes in Animals Exhibiting Immunoregulatory Defects. With 6 Figures.- Experimental Models and Systemic Lupus.- Autoimmunity: A Problem of Disordered Immunologic Regulation.- Chronic Infections of C-Type RNA Viruses.- Evidence for a Virus in Canine Systemic Lupus Erythematosus.- Viral Replication in Lymphocytes and the Pathogenesis of Connective Tissue Diseases. With 8 Figures.- Recent Approaches to Experimental Immune Complex Disease and Allergic Vasculitis.- Immune Complex Diseases: Cellular Mediators and the Pathogenesis of Inflammatory Tissue Injury Produced by Immune Complexes. With 1 Figures.- Antibody Affinity, Macrophage Function and Immunoregulation in Murine Immune Complex Disease. With 4 Figures.- Features of Human Spontaneous Vasculitis Reproduced Experimentally in Animals. Effects of Antiglobulins, C-Reactive Protein and Fibrin.- Mechanisms Involved in Clinical Allergic Vasculitis.- Significance of Anti-IgG Antibodies in Experimental Arthritis. With 5 Figures.- Immune Complex Arthritis — In Man and Experimental Animals. With 2 Figures.- Arthritis During the Course of Experimental or Natural Infection.- Rheumatoid Arthritis and the Virus Hypothesis. With 3 Figures.- Teno-Synovitis (Viral Arthritis) of Chickens.- Hemostasis, Fibrin Incorporation and Local Mesenchymal Reaction in Erysipelothrix Infection as a Model for Rheumatism Research. With 18 Figures.-Erysipelothrix Arthritis in Rabbits.- Mycoplasma Infection and Arthritis of Chickens.- Experimental Models of Streptococcal Arthritis: Pathogenetic Role of Streptococcal Products and Prostaglandins and Their Modification by Anti-Inflammatory Agents. With 20 Figures.- Control Mechanisms in Inflammatory Responses.- The Regulation of the Participation of Mononuclear Phagocytes in Inflammatory Responses. With 10 Figures.- The Kinetics of Chronic Inflammatory Cellular Infiltrates.- Pathology of Lymphoid Tissue in Rheumatoid Arthritis and Allied Diseases. With 16 Figures.- Lymphocyte Infiltration and Proliferation of Stroma Cells of Synovial Tissue in Rheumatoid Arthritis. With 6 Figures.- Aspects of Synovial Biodegradation. With 15 Figures.- An Effect of Joint Fluid on Blood Monocytes. With 1 Figures.- Should We Stimulate or Suppress the Inflammatory Response?.- Should we Suppress or Stimulate the Immune Response in Inflammation? With 3 Figures.- The Action of Anti-Inflammatory Drugs on the Lymphocyte-Macrophage Axis. With 3 Figures.- Problems in Analysing the Actions of Immunosuppressive Agents in Immuno-Inflammatory Disease. With 4 Figures.- Influence of Anti-Inflammatory Drugs on Connective Tissue Metabolism. With 11 Figures.- Final General Discussion and Résumé.