This volume presents selected contributions from the “Advanced Research Workshop on Explosives Detection” hosted by the Department of Information Engineering of the University of Florence, Italy in 2018. The main goal of the workshop was to find out how Science for Peace and Security projects in the field of Explosives Detection contribute to the development and/or refinement of scientific and technical knowledge and competencies. The findings of the workshop, presented in the last section of the book, determine future actions and direction of the SPS Programme in the field of explosives detection and management.The NATO Science for Peace and Security (SPS) Programme, promotes dialogue and practical cooperation between NATO member states and partner nations based on scientific research, technological innovation and knowledge exchange. Several initiatives were launched in the field of explosive detection and clearance, as part of NATO’s enhanced role in the international fight against terrorism. Experts and scientists from NATO members and partner countries have been brought together in multi-year projects, within the framework of the SPS Programme, to cooperate in the scientific research in explosive detection field, developing new technologies and methods to be implemented in order to detect explosive substances in different contexts.