Preface Acknowledgments Section I General Principles 1 1. Drug Invention and the Pharmaceutical Industry 2. Pharmacokinetics: The Dynamics of Drug Absorption, Distribution, Metabolism, and Elimination 3. Pharmacodynamics: Molecular Mechanisms of Drug Action 4. Drug Toxicity and Poisoning 5. Membrane Transporters and Drug Response 6. Drug Metabolism 7. Pharmacogenetics Section II Neuropharmacology 8. Neurotransmission: The Autonomic and Somatic Motor Nervous Systems 9. Muscarinic Receptor Agonists and Antagonists 10. Anticholinesterase Agents 11. Nicotine and Agents Acting at the Neuromuscular Junction and Autonomic Ganglia 12. Adrenergic Agonists and Antagonists 13. 5-Hydroxytryptamine (Serotonin) and Dopamine 14. Neurotransmission in the Central Nervous System 15. Drug Therapy of Depression and Anxiety Disorders 16. Pharmacotherapy of Psychosis and Mania 17. Pharmacotherapy of the Epilepsies 18. Treatment of Central Nervous System Degenerative Disorders 19. Hypnotics and Sedatives 20. Opioids, Analgesia, and Pain Management 21. General Anesthetics and Therapeutic Gases 22. Local Anesthetics 23. Ethanol 24. Drug Use Disorders and Addiction Section III Modulation of Pulmonary, Renal, and Cardiovascular Function 25. Drugs Affecting Renal Excretory Function 26. Renin and Angiotensin 27. Treatment of Ischemic Heart Disease 28. Treatment of Hypertension 29. Therapy of Heart Failure 30. Antiarrhythmic Drugs 31. Treatment of Pulmonary Arterial Hypertension 32. Blood Coagulation and Anticoagulant, Fibrinolytic, and Antiplatelet Drugs 33. Drug Therapy for Dyslipidemias Section IV Inflammation, Immunomodulation, and Hematopoiesis 34. Introduction to Immunity and Inflammation 35. Immunosuppressants and Tolerogens 36. Immune Globulins and Vaccines 37. Lipid-Derived Autacoids: Eicosanoids and Platelet-Activating Factor 38. Pharmacotherapy of Inflammation, Fever, Pain, and Gout 39. Histamine, Bradykinin, and Their Antagonists 40. Pulmonary Pharmacology 41. Hematopoietic Agents: Growth Factors, Minerals, and Vitamins Section V Hormones and Hormone Antagonists 42. Introduction to Endocrinology: The Hypothalamic-Pituitary Axis 43. Thyroid and Antithyroid Drugs 44. Estrogens, Progestins, and the Female Reproductive Tract 45. Androgens and the Male Reproductive Tract 46. Adrenocorticotropic Hormone, Adrenal Steroids, and the Adrenal Cortex 47. Endocrine Pancreas and Pharmacotherapy of Diabetes Mellitus and Hypoglycemia 48. Agents Affecting Mineral Ion Homeostasis and Bone Turnover Section VI Gastrointestinal Pharmacology 49. Pharmacotherapy for Gastric Acidity, Peptic Ulcers, and Gastroesophageal Reflux Disease 50. Gastrointestinal Motility and Water Flux, Emesis, and Biliary and Pancreatic Disease 51. Pharmacotherapy of Inflammatory Bowel Disease Section VII Chemotherapy of Infectious Diseases 52. General Principles of Antimicrobial Therapy 53. Chemotherapy of Malaria 54. Chemotherapy of Protozoal Infections: Amebiasis, Giardiasis, Trichomoniasis, Trypanosomiasis, Leishmaniasis, and Other Protozoal Infections 55. Chemotherapy of Helminth Infections 56. Sulfonamides, Trimethoprim-Sulfamethoxazole, Quinolones, and Agents for Urinary Tract Infections 57. Penicillins, Cephalosporins, and Other β-Lactam Antibiotics 58. Aminoglycosides 59. Protein Synthesis Inhibitors and Miscellaneous Antibacterial Agents 60. Chemotherapy of Tuberculosis, Mycobacterium avium Complex Disease, and Leprosy 61. Antifungal Agents 62. Antiviral Agents (Nonretroviral) 63. Treatment of Viral Hepatitis (HBV/HCV) 64. Antiretroviral Agents and Treatment of HIV Infection Section VIII Pharmacotherapy of Neoplastic Disease 65. General Principles in the Pharmacotherapy of Cancer 66. Cytotoxic Drugs 67. Pathway-Targeted Therapies: Monoclonal Antibodies, Protein Kinase Inhibitors, and Various Small Molecules 68. Hormones and Related Agents in the Therapy of Cancer Section IX Special Systems Pharmacology 69. Ocular Pharmacology 70. Dermatological Pharmacology 71. Environmental Toxicology: Carcinogens and Heavy Metals Appendices I. Principles of Prescription Order Writing and Patient Compliance II. Design and Optimization of Dosage Regimens: Pharmacokinetic Data Index