The two-volume set LNAI 10751 and 10752 constitutes the refereed proceedings of the 10th Asian Conference on Intelligent Information and Database Systems, ACIIDS 2018, held in Dong Hoi City, Vietnam, in March 2018. The total of 133 full papers accepted for publication in these proceedings was carefully reviewed and selected from 423 submissions. They were organized in topical sections named: Knowledge Engineering and Semantic Web; Social Networks and Recommender Systems; Text Processing and Information Retrieval; Machine Learning and Data Mining; Decision Support and Control Systems; Computer Vision Techniques; Advanced Data Mining Techniques and Applications; Multiple Model Approach to Machine Learning; Sensor Networks and Internet of Things; Intelligent Information Systems; Data Structures Modeling for Knowledge Representation; Modeling, Storing, and Querying of Graph Data; Data Science and Computational Intelligence; Design Thinking Based R&D, Development Technique,and Project Based Learning; Intelligent and Contextual Systems; Intelligent Systems and Algorithms in Information Sciences; Intelligent Applications of Internet of Thing and Data Analysis Technologies; Intelligent Systems and Methods in Biomedicine; Intelligent Biomarkers of Neurodegenerative Processes in Brain; Analysis of Image, Video and Motion Data in Life Sciences; Computational Imaging and Vision; Computer Vision and Robotics; Intelligent Computer Vision Systems and Applications; Intelligent Systems for Optimization of Logistics and Industrial Applications.