Methods in Neurosciences, Volume 7: Lesions and Transplantation describes the chemical and nonchemical production of lesions and preparation and development of transplants, implants, and grafts. This book consists of four sections—chemical and nonchemical lesioning; model systems utilizing lesioning; transplants, implants, and grafts; and assessment of lesions and transplants. In these sections, this volume discusses the excitotoxins as tools for producing brain lesions; use of acromelic acid for production of rat spinal lesions; and opioid and nonopioid antinociception as revealed by lesion studies. The endothelin-1-induced lesions in the brain as a new model of focal ischemia; fetal implants in the lesioned spinal cord of the rat; and hippocampal transplants in oculo are also elaborated. This book likewise covers the assessment of neurochemical function of brain transplants and in vitro electrophysiological analysis of in oculo. This publication is intended for neuroscientists, but is also beneficial to researchers conducting work on lesions and transplants.