Contents. List of Contributors. Intoduction. Sharon M. Dankwardt: Solid phase synthesis: applications to combinatorial libraries. Mohamed A. Iqbal and Mark A. Ator: Proteaspme inhibitors. Tariq Ghayur, Sheryl J. Hays and Robert V. Talanian: Caspase-1 (ICE) and other caspases as drug discovery targets: opportunities and progress. William A. Metz and Norton P. Peet: Elastase inhibitors. M. Anthony Leesnitzer, D. Mark Bickett, Marcia L. Moss and J. David Becherer: A high-throughput assay for the TNF conerting enzyme. Kenneth D. Rice and William R. Moore: Tryptase inhibitors. Falguni Dasgupta: Selectin antagonists. Kerry W. Fowler and David T. Crowe: Cell adhesion integrins as pharmaceutical targets. Brion W. Murray, Yoshitaka Satoh and Bernd Stein: Inhibitors of the MAPK pathway. Mark J. Suto and Anthony M. Manning: Inhibition of NF-kB. Terry L. Bowlin, Stephen D. Yanofsky and Herman Schreuder: IL-1 antagonist discovery. Mark A. Giembycz: Phosphodiesterase inhibitors for respiratory disease. Subject index

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