Brief Contents I. BASIC CELL PROCESSES: INTEGRATION AND COORDINATION Introduction to PhysiologyMolecular InteractionsCompartmentation: Cells and TissuesEnergy and Cellular MetabolismMembrane DynamicsCommunication, Integration, and Homeostasis II. HOMEOSTASIS AND CONTROL Introduction to the Endocrine SystemNeurons: Cellular and Network PropertiesThe Central Nervous SystemSensory PhysiologyEfferent Division: Autonomic and Somatic Motor ControlMusclesIntegrative Physiology I: Control of Body Movement III. INTEGRATION OF FUNCTION Cardiovascular PhysiologyBlood Flow and the Control of Blood PressureBloodMechanics of BreathingGas Exchange and TransportThe KidneysIntegrative Physiology II: Fluid and Electrolyte Balance IV. METABOLISM, GROWTH, AND AGING The Digestive SystemMetabolism and Energy BalanceEndocrine Control of Growth and MetabolismThe Immune SystemIntegrative Physiology III: ExerciseReproduction and Development

Emphasize “big picture” biological concepts and the integrative nature of how organ systems work together   EXPANDED!  Easy-to-Follow Instructions help students integrate informationby creating concept maps and flow charts.  ENHANCED! Figure 1.3 “Focus on…Mapping” now includes succinct hints, updated recommendations for creating electronic concept maps, and an illustrated 3-step example.NEW! A Ready-to-Go Teaching Module provides extensive teaching suggestions for instructors to guide students in creating concept maps.Mapping Exercises are included in the end-of-chapter Review Questions for most chapters. Unique Integrative Physiology chapters (Chapters 13, 20, and 25) ask students to step back and look at the big picture to learn how separate physiological processes work together in an integrated system. These chapters explore control of body movement, fluid and electrolyte balance, and exercise and demonstrate the emergent properties of the various body systems.Four core concepts in biology that are most related to physiology are introduced in Chapter 1, informed by recommendations from academic organizations including NSF, AAAS, HHMI, and AAMC.  The four themes explore structure-function relationships, biological energy use, information flow within an organism, and homeostasis and control systems that maintain homeostasis. Guide students to think critically and use information to solve real-world problems NEW! “Try it” Activities present a realworld research problem or classic experiment and guide students in analyzing the data and thinking like a scientist by considering different outcomes, designing a follow-up experiment, or forming a hypothesis. “Try it” Activity topics include Graphing (Chapter 1), Cell Membrane Models (Chapter 5), Action Potentials in Venus Flytraps (Chapter 8), SaltySweet Taste Experiment (Chapter 10), the FrankStarling Law of the Heart (Chapter 14), Insulin (Chapter 19) and Oral Rehydration Therapy (Chapter 21). NEW! An assignable version of each “Try it” activity is available in Mastering A&P, including coaching and feedback.   UPDATED! Figure 1.15 “Focus on…Graphing” now integrates instructions and example graphs more closely to immediately engage students in active learning, and concludes with the new “Try It” activity that students could complete in class or outside of class. NEW! A Ready-to-Go Teaching Module includes a wealth of teaching ideas to help students build and practice graphing skills. Running Problems explore a real-world disease or disorder that unfolds in short segments throughout the chapter.  Students can check their understanding by comparing their answers with those in Problem Conclusion at the end of each chapter. Related Running Problem Coaching Activities can be assigned in Mastering A&P.Questions throughout the chapter give students an opportunity to check their understanding. Figure Questions and Graph Questions ask students to think critically and analytically, providing frequent stop-and-think opportunities to reinforce important concepts while building visualization and graphing skills.  Answers to these questions appear at the end of the text, in Appendix A.  Concept Checks appear at intervals throughout the chapter and test students before they move on. End-of-chapter, 4-Level Review Questions help to build the student’s confidence as they progress from answering factual questions, to conceptual problems, to analytical exercises, and concluding with quantitative questions. The variety of questions also gives instructors flexibility in assigning homework from the text:Level 1 questions review basic facts and terms.Level 2 questions test the student's ability to comprehend and integrate the key concepts in the chapter. Level 3 exercises are real-world scenarios designed to develop problem-solving skills.Level 4 questions are quantitative questions that require mathematical skills.   Cover the right balance of fundamental physiology concepts along with exciting research developments NEW!  Carefully selected content updates have been added throughout the text to reflect the dynamic state of physiology research, including:Developments using Induced Pluripotent Stem Cells (iPSs)Updates on mechanisms of axonal transport and associated diseases: dynein, kinesin, fragile X, Alzheimer’s, and microcephalyNew information on the role of the kidney in hypertensionExtensive revisions in Chapter 24 on the Immune System, including 6 new figures and new discussions on long-lived plasma cells, mucosa-associated lymphoid tissue (MALT), self-antigens, negative selection, Zika virus, B cell receptors, regulatory T cells, and more. UPDATED! Easy-to-follow references direct learners to related content and mediaNEW! IP 2.0 integrated call-outs and Mastering Study Area references highlight practice opportunities and quizzes for students.Learning Outcomes appear at the beginning of every chapter to provide a learning framework for students, allowing them to easily test their knowledge after reading. Background Basics and Concept Links help students locate, revisit, and review topics they encounter. Carefully developed Art program helps students learn physiology more efficiently.Essentials Figures distill the basics of a topic into one or two pages, helping students to see the big picture of human physiology.  Instructors can assign related Mastering A&P coaching activities that explore these topics in greater depth. Anatomy Summary Figures provide succinct visual overviews of a physiological system from a macro to micro perspective.  Whether students are learning the anatomy for the first time or refreshing their memory, these summaries show the essential features of each system in a single figure.Reflex pathway maps and concept maps demonstrate at-a-glance complex physiological processes.Review Figures visually present foundational concepts that students may already be familiar with. Students may find it helpful to check out these figures before learning new physiology concepts.Additional “Focus On…” Figures highlight the anatomy and physiology of important organs, including the skin, bone marrow, the liver, the spleen, the thymus gland, and the pineal gland. Also available packaged with Mastering A&P or as an easy-to-use, standalone Pearson eText Mastering™ is the teaching and learning platform that empowers you to reach every student. By combining trusted author content with digital tools developed to engage students and emulate the office-hour experience, Mastering personalizes learning and improves results for each student. Features in the text are supported by Mastering A&P assignments, including new Interactive Physiology 2.0 tutorials, Dynamic Study Modules, Learning Catalytics, 3D animations, lab study tools, Get Ready for A&P, plus a variety of Art Labeling Questions, Clinical problem-solving activities, and more. Learn more about Mastering A&P.   Guide students to think critically and use information to solve real-world problems NEW! “Try it” Coaching Activities present a real-world research problem or classic experiment and guide students in analyzing the data and thinking like a scientist by considering different outcomes, designing a follow-up experiment, or forming a hypothesis. “Try it” Activities are included in the text and explore Graphing (Chapter 1), Cell Membrane Models (Chapter 5), Action Potentials in Venus Flytraps (Chapter 8), SaltySweet Taste Experiment (Chapter 10), the FrankStarling Law of the Heart (Chapter 14), Insulin (Chapter 19) and Oral Rehydration Therapy (Chapter 21). Phys in Action! Video Tutors and Coaching Activities were developed by two of Dee Silverthorn’s teaching assistants to help students visualize and master challenging physiological concepts using laboratory demonstrations and other realworld applications. Instructors can assign the coaching activities as homework or students can access them in the Mastering A&P Study Area.Nurses Need Physiology Case Studies are multi-step coaching activities that guide students through the steps of diagnosing and treating patients in realworld clinical scenarios.Running Problem Coaching Activities are based on the Running Problems in the text that are interspersed throughout the chapters and include Socratic hints and feedback to help students develop critical thinking skills.   Coach students through challenging Human Physiology topics EXPANDED! Interactive Physiology 2.0 helps students advance beyond memorization to a genuine understanding of complex physiological processes. Now fully accessible on all mobile devices, IP 2.0 tutorials feature new graphics, quicker navigation, and more robust activities where students can explore, experiment, and predict. New IP 2.0 modules include: Generation of an Action Potential, Resting Membrane Potential, Electrical Activity of the Heart, Cardiac Output, Factors Affecting Blood Pressure, and Cardiac Cycle.  Forthcoming modules - scheduled for Fall 2018 release - include Glomerular Filtration, Events at Neuromuscular Junction and Excitation-Contraction Coupling. IP 2.0 tutorials are assignable as coaching activities in Mastering A&P.  NEW!  Interactive Physiology Animations from the original award-winning Interactive Physiology tutorial program have been converted to animations to accommodate learners using a wide range of web browsers and mobile devices. IP Animations are assignable as coaching activities in Mastering A&P. Essentials Figure Coaching Activities are based on the Essentials Figures in the text, which blends narrative explanations and clear visuals that better enable students to visualize difficult concepts and physiological processes. PhysioEx Laboratory Simulations offer a supplement or substitute for wet labs due to cost, time, or safety concerns. A&P Flix™ Coaching Activities offer stunning 3D visuals of core and complex concepts with in-depth assessments to test student understanding. References to relevant A&P Flix animations now appear within chapters in the text.   Encourage students to study anywhere, anytime NEW! Pearson eText, optimized for mobile, seamlessly integrates videos and other rich media with the text and gives students access to their textbook anytime, anywhere. Pearson eText is available with Mastering A&P when packaged with new books, or as an upgrade students can purchase online. The Pearson eText mobile app offers: Offline access on most iOS and Android phones/tablets.Accessibility (screen-reader ready)Configurable reading settings, including resizable type and night reading modeInstructor and student note-taking, highlighting, bookmarking, and search toolsEmbedded videos for a more interactive learning experience Dynamic Study Modules help students study effectively on their own by continuously assessing their activity and performance in real time. Students complete a set of questions and indicate their level of confidence in their answer. Questions repeat until the student can answer them all correctly and confidently. These are available as graded assignments prior to class and are accessible on smartphones, tablets, and computers. NEW! Instructors can now remove questions from Dynamic Study Modules to better fit their course.   Tools for you, the instructor NEW! Ready-to-Go Teaching modules created for and by instructors model effective teaching strategies. The modules incorporate the best that the text, Mastering A&P, and Learning Catalytics have to offer and guide instructors through using these resources in the most effective way. Instructors can access the modules through the Instructor Resources area of Mastering A&P along with corresponding, customizable pre-built assignments. Watch our video to learn about Ready-to-Go Teaching modules. Learning Catalytics™ helps generate class discussion, customize lectures, and promote peer-to-peer learning with real-time analytics. Learning Catalytics acts as a student response tool that uses students’ smartphones, tablets, or laptops to engage them in more interactive tasks and thinking. NEW! Upload a full PowerPoint® deck to easily create slide questions.Help your students develop critical thinking skills.Monitor responses to find out where your students are struggling.Rely on real-time data to adjust your teaching strategy.Automatically group students for discussion, teamwork, and peer-to-peer learning. Pearson eText allows educators to easily share their own notes with students so they see the connection between their reading and what they learn in class–motivating them to keep reading, and keep learning. Portable access lets students study on the go, even offline. And, reading analytics offer insight into how students use the eText, helping educators tailor their instruction. Learn more about Pearson eText.   Check out the preface for a complete list of features and what's new in this edition.

Emphasize “big picture” biological concepts and the integrative nature of how organ systems work together   Expanded Easy-to-Follow Instructions help students integrate information by creating concept maps and flow charts.  Enhanced Figure 1.3 “Focus on…Mapping” now includes succinct hints, updated recommendations for creating electronic concept maps, and an illustrated 3-step example.A Ready-to-Go Teaching Module provides extensive teaching suggestions for instructors to guide students in creating concept maps. Guide students to think critically and use information to solve real-world problems  “Try it” Activities present a realworld research problem or classic experiment and guide students in analyzing the data and thinking like a scientist by considering different outcomes, designing a follow-up experiment, or forming a hypothesis. “Try it” Activity topics include Graphing (Chapter 1), Cell Membrane Models (Chapter 5), Action Potentials in Venus Flytraps (Chapter 8), SaltySweet Taste Experiment (Chapter 10), the FrankStarling Law of the Heart (Chapter 14), Insulin (Chapter 19) and Oral Rehydration Therapy (Chapter 21). An assignable version of each “Try it” activity is available in Mastering A&P, including coaching and feedback.   Updated Figure 1.15 “Focus on…Graphing” now integrates instructions and example graphs more closely to immediately engage students in active learning, and concludes with the new “Try It” activity that students could complete in class or outside of class. A Ready-to-Go Teaching Module includes a wealth of teaching ideas to help students build and practice graphing skills. Cover the right balance of fundamental physiology concepts along with exciting research developments Carefully selected content updates have been added throughout the text to reflect the dynamic state of physiology research, including:Developments using Induced Pluripotent Stem Cells (iPSs)Updates on mechanisms of axonal transport and associated diseases: dynein, kinesin, fragile X, Alzheimer’s, and microcephalyNew information on the role of the kidney in hypertensionExtensive revisions in Chapter 24 on the Immune System, including 6 new figures and new discussions on long-lived plasma cells, mucosa-associated lymphoid tissue (MALT), self-antigens, negative selection, Zika virus, B cell receptors, regulatory T cells, and more. Updated Easy-to-follow references direct learners to related content and mediaIP 2.0 integrated call-outs and Mastering Study Area references highlight practice opportunities and quizzes for students.Learning Outcomes appear at the beginning of every chapter to provide a learning framework for students, allowing them to easily test their knowledge after reading. Background Basics and Concept Links help students locate, revisit, and review topics they encounter. Carefully developed Art program helps students learn physiology more efficiently.Additional “Focus On…” Figures highlight the anatomy and physiology of important organs, including the skin, bone marrow, the liver, the spleen, the thymus gland, and the pineal gland.   Also available packaged with Mastering A&P or as an easy-to-use, standalone Pearson eText   Guide students to think critically and use information to solve real-world problems  “Try it” Coaching Activities present a realworld research problem or classic experiment and guide students in analyzing the data and thinking like a scientist by considering different outcomes, designing a follow-up experiment, or forming a hypothesis. “Try it” Activities are included in the text and explore Graphing (Chapter 1), Cell Membrane Models (Chapter 5), Action Potentials in Venus Flytraps (Chapter 8), SaltySweet Taste Experiment (Chapter 10), the FrankStarling Law of the Heart (Chapter 14), Insulin (Chapter 19) and Oral Rehydration Therapy (Chapter 21).   Coach students through challenging Human Physiology topics Expanded Interactive Physiology 2.0 helps students advance beyond memorization to a genuine understanding of complex physiological processes. Now fully accessible on all mobile devices, IP 2.0 tutorials feature new graphics, quicker navigation, and more robust activities where students can explore, experiment, and predict. New IP 2.0 modules include: Generation of an Action Potential, Resting Membrane Potential, Electrical Activity of the Heart, Cardiac Output, Factors Affecting Blood Pressure, and Cardiac Cycle.  Forthcoming modules - scheduled for Fall 2018 release - include Glomerular Filtration, Events at Neuromuscular Junction and Excitation-Contraction Coupling. IP 2.0 tutorials are assignable as coaching activities in Mastering A&P.  Interactive Physiology Animations from the original award-winning Interactive Physiology tutorial program have been converted to animations to accommodate learners using a wide range of web browsers and mobile devices. IP Animations are assignable as coaching activities in Mastering A&P.   Encourage students to study anywhere, anytime Pearson eText, optimized for mobile, seamlessly integrates videos and other rich media with the text and gives students access to their textbook anytime, anywhere. Pearson eText is available with Mastering A&P when packaged with new books, or as an upgrade students can purchase online. The Pearson eText mobile app offers: Offline access on most iOS and Android phones/tablets.Accessibility (screen-reader ready)Configurable reading settings, including resizable type and night reading modeInstructor and student note-taking, highlighting, bookmarking, and search toolsEmbedded videos for a more interactive learning experience   Tools for you, the instructor Ready-to-Go Teaching modules created for and by instructors model effective teaching strategies. The modules incorporate the best that the text, Mastering A&P, and Learning Catalytics have to offer and guide instructors through using these resources in the most effective way. Instructors can access the modules through the Instructor Resources area of Mastering A&P along with corresponding, customizable pre-built assignments. Watch our video to learn about Ready-to-Go Teaching modules. Learning Catalytics™ helps generate class discussion, customize lectures, and promote peer-to-peer learning with real-time analytics. Learning Catalytics acts as a student response tool that uses students’ smartphones, tablets, or laptops to engage them in more interactive tasks and thinking. NEW! Upload a full PowerPoint® deck to easily create slide questions. Pearson eText allows educators to easily share their own notes with students so they see the connection between their reading and what they learn in class–motivating them to keep reading, and keep learning. Portable access lets students study on the go, even offline. And, reading analytics offer insight into how students use the eText, helping educators tailor their instruction. Learn more about Pearson eText. Check out the preface for a complete list of features and what's new in this edition.