Pharmacogenomics is the basis of personalized medicine which will be the medicine of the future. Through both reducing the numbers of adverse drug reactions and improving the use of existing drugs in targeted populations, pharmacogenomics represents a real advance on traditional therapeutic drug monitoring. Pharmacogenomics in Clinical Therapeutics provides an introduction to the principles of pharmacogenomics before addressing the pharmacogenomic aspects of key therapeutic areas such as warfarin therapy, cancer chemotherapy, therapy with immunosuppressants, antiretroviral therapy, and psychoactive drugs. It also includes methods of pharmacogenomic testing and the pharmacogenomic aspects of drug–drug interactions. From a team of expert contributors, Pharmacogenomics in Clinical Therapeutics is a comprehensive overview of the current state of pharmacogenomics in pharmacotherapy for all clinicians, pharmacologists and clinical laboratory professionals. It is also a guide for practicing clinicians and health care professionals to the basic principles of pharmacogenomics, laboratory tests currently available to aid clinicians, and the future promise of this developing field.
Les mer
Pharmacogenomics is the process of analyzing patients' genes to predict the onset of adverse reactions or forecast the effectiveness of therapeutic drugs. This useful text is written to discuss both the theory and the clinical application of the principles of pharmacogenomics.
Les mer
List of Contributors, vii Preface, ix 1 Pharmacogenomics Principles: Introduction to Personalized Medicine, 1 Parvaz Madadi, PhD and Gideon Koren, MD 2 Traditional Therapeutic Drug Monitoring and Pharmacogenomics: Are They Complementary? 15 Christine L.H. Snozek, PhD, Loralie J. Langman, PhD, and Amitava Dasgupta, Ph.D 3 Pharmacogenomics Aspect of Warfarin Therapy, 26 Matthew D. Krasowski, MD, PhD 4 Pharmacogenetics and Cancer Chemotherapy, 39 Christine L.H. Snozek 5 Pharmacogenomic Considerations in Anesthesia and Pain Management, 53 Christine M. Formea, PharmD and Wayne T. Nicholson, MD, PharmD 6 Pharmacogenomics of Immunosuppressants, 70 Nicolas Picard, PharmD, PhD and Pierre Marquet, MD, PhD 7 Pharmacogenomics of Cardiovascular Drugs, 98 Linnea M. Baudhuin, PhD 8 Pharmacogenomic Aspects of Antiretroviral Therapy, 127 Natella Y. Rakhmanina, MD, PhD and John N. van den Anker, MD, PhD 9 Pharmacogenetics of Psychoactive Drugs, 144 Jorge L. Sepulveda, MD, PhD 10 Pharmacogenomic Aspects of Adverse Drug–Drug Interactions, 176 Loralie J. Langman, PhD and Christine L.H. Snozek, PhD 11 Microarray Technology and Other Methods in Pharmacogenomics Testing, 185 Jorge L. Sepulveda, MD, PhD 12 Pharmacogenetic Testing in the Clinical Laboratory Environment, 201 Mark P. Borgman, PhD and Mark W. Linder, PhD Index, 225
Les mer
Pharmacogenomics is the basis of personalized medicine which will be the medicine of the future. Through both reducing the numbers of adverse drug reactions and improving the use of existing drugs in targeted populations, pharmacogenomics represents a real advance on traditional therapeutic drug monitoring. Pharmacogenomics in Clinical Therapeutics provides an introduction to the principles of pharmacogenomics before addressing the pharmacogenomic aspects of key therapeutic areas such as warfarin therapy, cancer chemotherapy, therapy with immunosuppressants, antiretroviral therapy, and psychoactive drugs. It also includes methods of pharmacogenomic testing and the pharmacogenomic aspects of drug–drug interactions. From a team of expert contributors, Pharmacogenomics in Clinical Therapeutics is a comprehensive overview of the current state of pharmacogenomics in pharmacotherapy for all clinicians, pharmacologists and clinical laboratory professionals. It is also a guide for practicing clinicians and health care professionals to the basic principles of pharmacogenomics, laboratory tests currently available to aid clinicians, and the future promise of this developing field.
Les mer
“This book is unique in its focus on the application of pharmacogenomics in clinical therapeutics.”  (Doody’s, 19 January 2013)  

Produktdetaljer

ISBN
9780470657348
Publisert
2012-02-17
Utgiver
Vendor
Wiley-Blackwell
Vekt
680 gr
Høyde
254 mm
Bredde
196 mm
Dybde
18 mm
Aldersnivå
P, 06
Språk
Product language
Engelsk
Format
Product format
Innbundet
Antall sider
256

Biographical note

Amitava Dasgupta, Ph.D, DABCC, FACB, Professor of Pathology and Laboratory Medicine, University of Texas Health Sciences Center at Houston, Houston, TX.

Loralie J. Langman, Ph.D, DABCC, FACB, Associate Professor of Laboratory Medicine, Mayo Clinic, Rochester, MN.