PREFACE xi Unit 1 Introduction 1 The Chemical Basis of Life 1 2 Aqueous Chemistry 24 Unit 2 Biomolecules: Structure and Functions 3 Flow of Genetic Information 52 4 Structure of Proteins 85 5 Functions of Proteins 119 6 How Enzymes Work 154 7 Enzyme Kinetics and Inhibition 183 8 Lipids and Biological Membranes 215 9 Transport Through Membrane 235 10 Biochemical Signaling 260 11 Carbohydrates 283 Unit 3 Metabolism 12 Metabolism and Bioenergetics 301 13 Glucose Metabolism 329 14 The Citric Acid Cycle 362 15 Oxidative Phosphorylation 385 16 Photosynthesis 411 17 Lipid Metabolism 432 18 Nitrogen Metabolism 464 19 Mammalian Fuel Metabolism: Regulation 497 Unit 4 Gene Replication and Expression 20 DNA Replication and Repair 519 21 Transcription and RNA 551 22 Synthesis of Proteins 580 GLOSSARY G-1 ODD-NUMBERED SOLUTIONS S-1 INDEX I-1

Pratt's ESSENTIAL BIOCHEMISTRY Pratt's Essential Biochemistry, Global Edition aims to provide a solid foundation in biochemistry, presenting complete, up-to-date information while focusing on the practical aspects of biochemistry as it applies to human health, nutrition and disease. It presents a broad, but not overwhelming coverage of basic biochemical concepts that focus on the chemistry behind biology, structure-function relationships, transformation of energy and how genetic information is stored and made accessible. It relates these concepts to practical knowledge as well as providing many problem-solving opportunities to enhance skills. This book is authorized for sale in Europe, Asia, Africa and the Middle East only and may not be exported. The content is materially different than products for other markets including the authorized U.S. counterpart of this title. Exportation of this book to another region without the Publisher's authorization may be illegal and a violation of the Publisher's rights. The Publisher may take legal action to enforce its rights