This book presents contributions related to new research results presented at the 27th International Conference on Difference Equations and Applications, ICDEA 2022, that was held at CentraleSupélec, Université Paris-Saclay, France, under the auspices of the International Society of Difference Equations (ISDE), July 18–22, 2022. The book aims not only to disseminate these results but to foster further advances in the fields of difference equations and discrete dynamical systems. Also included are applications to economic growth modeling, population dynamics, epidemic modeling, game theory, control systems, and network analysis. The target audience for the book includes Ph.D. students, researchers, educators, and practitioners in these fields.