This volume contains the proceedings of the international HPCN Europe 2000 event which was held in the Science and Technology Centre Watergraafsmeer, Amsterdam, the Netherlands, May 8-10, 2000. HPCN (High Performance Computing and Networking)Europeeventwas organized for the r st time in 1993 in Amsterdam as the result of several i- tiatives in Europe, the United States of America, and Japan. Succeeding HPCN events were held in Munich (1994), Milan (1995), Brussels (1996), and Vienna (1997), returning to Amsterdam in 1998 to stay. The HPCN event keeps growing and advancing every year, and this year the event consisted of the scientic conference, focused workshops, and several associated events. Theplenary lectures werepresented bysix renowned speakers: { Henk van der Vorst, University of Utrecht, The Netherlands: Giant Eig- problems within Reach, { WolfgangGentzsch, CTO, GridwareInc., Germany: The Information Power Grid is Changing our World, { Bernard Lecussan, SupAero and ONERA/CERT/DTIM, France: Irregular Application Computations on a Cluster of Workstations, { Miguel Albrecht, European Southern Observatory, Garching, Germany: Technologies for Mining Terabytes of Data, { HansMeinhardt, Max-Planck-Institut,Germany: The Algorithmic Beauty of Sea Shells,and { IngoAugustin,CERN,Geneva,Switzerland: Towards Multi-petabyte Storage Facilities. Theconference consisted ofparalleltrackspresenting 52selected papers, andone track presenting 25 posters. The areas covered in the conference include: Ind- trial and General End-User Applications of HPCN, Computational and C- puter Sciences, and this year the scope of the conference was further expanded by an additional area to emphasize the information management aspects, and the importance of the web-based cooperative application infrastructures.