Suitable for graduate students, post-doctoral fellows, basic and clinical immunologists, and any physician treating diseases in which immunologic mechanisms play a role, this title offers extensive coverage of molecular biology that explains the molecular dynamics underlying immune disorders and their treatment.

Section I. Introduction to Immunology

1 The Immune System
William E. Paul

2 History of Immunology
Steven Greenberg

Section II. Organization and Evolution of the Immune System

3 Lymphoid Tissues and Organs
Eitan M. Akirav, Noelia Alonso-Gonzalez, Lucy A. Truman, and Nancy H. Ruddle

4 Evolution of the Immune System
Martin F. Flajnik

Section III. Immunoglobulins and B Lymphocytes

5 Immunoglobulins: Structure and Function
Harry W. Schroeder

6 Immunoglobulins: Molecular Genetics
Edward E. Max and Sebastian Fugmann

7 Antigen-Antibody Reactions
Jay A. Berzofsky and Ira Berkower

8 B Lymphocyte Development
Richard R. Hardy

9 B Lymphocyte Receptors, Signaling Mechanisms, and Activation
Akanksha Chaturvedi, Angel Davey, Wanli Liu, Hae Won Sohn, and Susan K. Pierce

10 B Lymphocyte Responses
Michael McHeyzer-Williams

Section IV. T Lymphocytes

11 T Lymphocyte Receptors
Mark M. Davis

12 T Lymphocyte Signaling Mechanisms
Takashi Saito

13 T Lymphocyte Developmental Biology
Ellen V. Rothenberg and Ameya Champhekar

14 Peripheral T Lymphocyte Responses and Function
Marc K. Jenkins

Section V. The Intersection of Innate and Adaptive Immunity

15 The Innate Immune System
Luke A. J. O’Neill

16 Dendritic Cells
Michel C. Nussenzweig

17 Natural Killer Cells
Wayne M. Yokoyama

18 CD1d-restricted NKT Cells
Albert S. Bendelac

19 Macrophages and Phagocytosis
Siamon Gordon

20 Granulocytes and Mast Cells
Patrizia Scapini, Nicola Tamassia, Carlo Pucillo, and Marco A. Cassatella

21 The Major Histocompatibility Complex and its Proteins
David H. Margulies

22 Antigen Processing and Presentation
Ted H. Hansen and Paul A. Roche

Section VI. Induction, Regulation, and Effector Functions of the Immune Response

23 Immunogenicity and Antigen Structure
Jay A. Berzofsky

24 Fc Receptors and Their Role in Immune Regulation and Inflammation
Jeffrey V. Ravetch and Falk Nimmerjahn

25 Type I Cytokines and Interferons
Warren J. Leonard

26 Interleukin-1 Family Cytokines
Charles A. Dinarello and Mihai G. Netea

27 TNF-related Cytokines in Immunity
Carl F. Ware

28 Chemokines
Philip M. Murphy

29 Helper T Cell Differentiation and Plasticity
John J. O’Shea

30 Programmed Cell Death
Andrew L. Snow and Michael J. Lenardo

31 Immunological Memory
Shane Crotty, Susan M. Kaech, and Stephen P. Schoenberger

32 Immunological Tolerance
Pamela S. Ohashi

33 Regulatory/Suppressor T Cells
Ethan M. Shevach

34 Mucosal Immunity and Microbiome
Yasmine Belkaid

35 Neurophysiological Reflex Mechanisms in Immunology
Chavan and Kevin J. Tracey

36 Complement
B. Paul Morgan

37 Cell-mediated Cytotoxicity
Judy Lieberman

Section VII. Immunity to Infectious Agents

38 The Immune Response to Parasites
Thomas A. Wynne, David L. Sacks, Alan Sher, and Eleanor M. Riley

39 Immunity to Viruses
Hildegund C.J. Ertl

40 Immunity to Intracellular Bacteria
Anca Dorhoi, Stephen T. Reece, and Stefan H. E. Kaufmann

41 Immunity to Extracellular Bacteria
Moon H. Nahm and Jannet Katz

42 Immunology of HIV Infection
Bruce Walker

43 Vaccines
Ennio De Gregorio, Ugo D’Oro, Sylvie Bertholet, and Rino Rappuoli

Section VIII. Immunologic Mechanisms in Disease

44 Organ-Specific Autoimmunity
Ken T. Coppieters, Matthias G. von Herrath, and Dirk Homann

45 Allergy
Marsha Wills-Karp

46 Transplantation Immunology
Megan Sykes

47 Cancer Immunology
Hans Schreiber

48 Inborn Errors of Immunity
Jean-Laurent Casanova, Mary Ellen Conley, and Luigi D. Notarangelo