Natural History of Hypertrophic Cardiomyopathy.- Pathology and Pathophysiology.- Genetics of HCM and Role of Genetic Testing.- Family Screening and Cascade Testing.- Epiphenomena in Hypertrophic Cardiomyopathy: Acquired von Willebrand Syndrome.- Acute left ventricular ballooning in obstructive hypertrophic cardiomyopathy.- Epicardial and Microvascular Ischemia: Implications, Diagnosis, and Management.- Approach to Diagnosis: Echocardiography.- Cardiac MRI in Diagnosis and Management.- Phenocopies of HCM.- Assessment of Heart Failure and Angina: Invasive and Non-invasive Methods.- Assessment of Syncope.- Pediatric Diagnosis and Management.- Sudden Cardiac Death Risk Assessment.- Youth and Athletic Screening: Rationale, Methods, and Outcome.- Lifestyle Modification: Exercise and Sports.- Lifestyle Modification: Exercise and Sports.- Diet, Nutrition, and Managing Obesity.- Traditional Medical Therapy.- Hypertension and Hypertrophic Cardiomyopathy.- Diagnosing and Managing Pulmonary and Right-Sided Heart Disease: Pulmonary Hypertension, Right Ventricular Outflow Pathology, and Sleep Apnea.- Indications and Outcome of PPM and ICD Placement.- Management of Arrhythmia.- Indications for and Individualization of Septal Reduction Therapy.- Surgical Myectomy and Novel Surgical Techniques.- Alcohol Septal Ablation and Novel Interventional Techniques.- Managing the Critical Patient with HCM.- End-Stage Diastolic and Systolic Heart Failure.- End-Stage Diastolic and Systolic Heart Failure.- Cardiac Myosin Inhibitors and Future Directions in Medical Therapy.- Approach to the Initial and Follow-Up Visits.- Evaluation and Management of Hypertrophic Cardiomyopathic Patients Through Noncardiac Surgery and Pregnancy.- Building a Hypertrophic Cardiomyopathy Center of Excellence.- Professional and Patient-Related Support Groups and Advocacy.- Professional and Patient-Related Support Groups and Advocacy.- Longitudinal Case-Based Presentations in HCM.

This extensively updated textbook provides a comprehensive review of hypertrophic cardiomyopathy (HCM), the most common genetic disorder of the heart characterized by dysfunctional contractility at the sarcomere level. The disease produces abnormal and often focal hypertrophy on a macroscopic level that further impairs cardiac performance and may lead to life-threatening arrhythmias. There have been vast changes in the understanding and management of the disease in recent years, in addition to increased awareness and prevalence. Accordingly, HCM Centers of Excellence have rapidly grown across the world that are in need of detailed information on the topic.  This edition provides a practical yet comprehensive approach to both diagnosis and management, establishing evidence-based best practice for all scenarios.

Hypertrophic Cardiomyopathy provides readers with key points and critical clinical pearls to assist them in managing patients. Every chapter has been updated to reflect the huge changes across the topic over the past 5 years. Each chapter is supplemented by a series of relevant instructional multiple choice questions and their solutions are included in the supplemental FlashCards. All aspects of treatment are covered – traditional and novel medications, pacemakers and defibrillators, and invasive septal reduction therapy (both surgical myectomy and alcohol septal ablation) – in addition to genetics, family screening, lifestyle concerns and athletic screening. Nuanced areas such as HCM in pregnancy or in the critical care unit, or the approach to HCM and hypertension, are also addressed.  The practical approach has been reinforced with an expanded emphasis on creating a Center of Excellence, how to facilitate the multi-disciplinary approach, and on real-world case-based reviews and discussions.

Written by experts across the globe, this is an essential textbook for cardiology professionals from trainee to board-certified physician, including important information for interventional cardiologists, cardiac surgeons, cardiac imagers, critical care physicians, sports medicine physicians, genetic counsellors and electrophysiologists.