As researchers continue to make enormous progress in mapping disease genes, exciting, novel, and complex analyses have emerged. In Linkage Disequilibrium and Association Mapping: Analysis and Applications, scientists from around the world, who are leaders in this field, contribute their vast experience and expertise to produce a comprehensive and fascinating text for researchers and clinicians alike.

The volume comprises four general sections: the first presents an overview and historical basis of the subject. The second section considers the developing methodology and recent findings from studies which have characterized the genome-wide linkage disequilibrium structure in enormous detail. The following section examines all aspects of disease association mapping methodology, and the final two chapters review the early successes in mapping genes involved in two of the most important human diseases: asthma and type 2 diabetes.

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<p>As researchers continue to make enormous progress in mapping disease genes, exciting, novel, and complex analyses have emerged.</p>
Linkage Disequilibrium and Association Mapping.- A History of Association Mapping.- Linkage Disequilibrium Maps and Location Databases.- LDMAP.- Linkage Disequilibrium as a Tool for Detecting Signatures of Natural Selection.- The Genetic Basis of Complex Traits.- Linkage Disequilibrium Mapping for Complex Disease Genes.- Linkage Disequilibrium Maps and Disease-Association Mapping.- Coalescent Methods for Fine-Scale Disease-Gene Mapping.- Family-Based Linkage Disequilibrium Tests Using General Pedigrees.- Association Studies Using Familial Cases.- Association Mapping Using Pooled DNA.- Selecting Single-Nucleotide Polymorphisms for Association Studies With SNPbrowser™ Software.- Avoiding False Discoveries in Association Studies.- Gene Mapping in Asthma-Related Traits.- Identifying Susceptibility Variants for Type 2 Diabetes.
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As researchers continue to make enormous progress in mapping disease genes, exciting, novel, and complex analyses have emerged. In Linkage Disequilibrium and Association Mapping: Analysis and Applications, scientists from around the world, who are leaders in this field, contribute their vast experience and expertise to produce a comprehensive and fascinating text for researchers and clinicians alike.

The volume comprises four general sections: the first presents an overview and historical basis of the subject. The second section considers the developing methodology and recent findings from studies which have characterized the genome-wide linkage disequilibrium structure in enormous detail. The following section examines all aspects of disease association mapping methodology, and the final two chapters review the early successes in mapping genes involved in two of the most important human diseases: asthma and type 2 diabetes.

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Chapters written by world-renowned leaders in the field of gene-mapping A clear synthesis of all important methodology that has been developed in tis complex research field Cutting-edge analysis of the most up-to-date and preeminent information available
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Produktdetaljer

ISBN
9781617377099
Publisert
2010-11-19
Utgiver
Humana Press Inc.
Høyde
229 mm
Bredde
152 mm
Aldersnivå
Research, P, 06
Språk
Product language
Engelsk
Format
Product format
Heftet

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