A biofilm is a collection of microbial cells that have adhered to
biotic surfaces such as plant cuticles or animal epithelia, as well as
abiotic surfaces such as rocky substratum or catheter exteriors. The
life cycle of a microorganism includes the fundamental process of
biofilm formation for survival in diverse and harsh environments since
it is a protected mode of growth allowing colonisation of new habitats
by dispersal of microbes from the microbial clusters. The biofilm
bound microorganisms remain embedded in an extracellular polymeric
matrix that protects the indwelling cells from surfactants, biocides,
several invaders like protozoans, and defences offered by the hosts
like phagocytic cells. The biofilm bound recalcitrant microbes induce
chronic and nosocomial diseases, posing a serious threat to public
health. It has been observed that various antimicrobial drugs are able
to successfully remove the planktonic (freely suspended) states of
microbes as compared to the sessile (substrate-bound) forms, thus
resulting in the development of antimicrobial resistance. Modern
pharmacological strategies targeting the biofilm matrix differ from
the conventional methods of antibiotic usage. This includes the use of
natural compounds such as plant bioactive molecules, antimicrobial
peptides, green synthesised nanoparticles, or secondary metabolites
from other organisms that not only prevent the rise of antimicrobial
resistance but are also safe for the host tissues. Biofilm Associated
Antimicrobial Resistance and Its Recovery provides a detailed and
systematic review of alternative pharmacological developments in the
field of biofilm research. Features: A narrative overview of the
mechanism of biofilm formation and its role in the emergence of
antimicrobial resistance Recent research in the development of
antibiofilm remedies involving biogenic compounds Advancements in
biofilm detection methodologies with cutting-edge technologies This
book serves as a resource for researchers who need to understand and
analyze the progression of events during microbial biofilm formation,
as well as design safer methodologies for its successful eradication.
It may also be used as a textbook for a graduate level course in
microbiology or microbial biotechnology.
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Produktdetaljer
ISBN
9781003801436
Publisert
2023
Utgave
1. utgave
Utgiver
Taylor & Francis
Språk
Product language
Engelsk
Format
Product format
Digital bok
Forfatter