One hardly always receives due credit for working out a general theory. It is more enticing to be successful in discovering new phenomena of tangible facts even if they are particular ones. The great technical opportunities which now exist and the new methods of investigation which recently seemed to be fantastic have made that even more enticing. Therefore, the establishment of general regu- larities seems to be an abstract occupation whose significance is not always clear. Nevertheless, a general theory should be elaborated. Factual material should be systematized and generalized as it accumu- lates. As an increasing amount of data is obtained, it becomes increasingly urgent to ascertain the general regularities which determine the typical mechanisms of individual phenomena. Re- searchers approach these aspects of scientific activity in different ways. Some of them are interested in analyzing the specifics of a phenomenon, while others try to find a general regularity in an individual fact and look for its confirmation in new material. Both of these indispensable forms of research have been reflected in this book.
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General Theory.- 1 - Determinant Structures as Functional Formations. The Determinant Principle.- Determinant Structures in the Spinal Cord.- Role of the Determinant in the Formation and Activity of the Complexes of Epileptic Foci in the Cerebral Cortex.- Realization of the Effects of the Determinant and its Interactions with the Subordinate Structures.- Forms of Determination.- Determinant and Dominant Relations.- Some Theoretical and Practical Aspects.- Summary.- 2 - Generators of Pathologically Enhanced Excitation in Various Areas of the Central Nervous System.- GPEE in the Spinal Cord's Efferent Output.- GPEE in the System of Propriospinal Neurons.- GPEE in the Bulbar Giant-Cell Nucleus.- GPEE in the Lateral Geniculate Nucleus.- GPEE in the Cerebral Cortex.- Summary.- 3 - Functional Organization and Properties of GPEE and the Mechanisms of its Formation.- Functional State of the Neuronal Populations of GPEE.- Critical Mass of Neurons which Constitute GPEE.- GPEE Power.- Positive Neuronal Connections in GPEE Activity.- Replacement of Inhibitory Effects by Exciting Effects in the Populations of GPEE Neurons.- Throughput Capacity of the GPEE Output Neurons.- Some Features of GPEE's Activity.- Trigger Stimulation.- Some Terminological Points.- Summary.- 4 - Hyperactive Determinant Structures and Pathologic Systems.- Physiological System.- Pathologic System.- Pathologic System's Resistance.- Disorganization and Disintegration of Systemic Activity.- Pathologic Systems and Neuropathologic Syndromes.- Summary.- Modeling Neuropathologic Syndromes.- 5 - Methodological Approaches.- Summary.- 6 - Generalized Spinal Myoclonia.- Summary.- 7 - Vestibulopathy.- Summary.- 8 - Photogenic Epilepsy.- Summary.- 9 - Pain Syndromes of Central Origin.- Spinal Pain Syndrome.- Trigeminal Neuralgia.- Pain Syndrome of Thalamic Origin.- Models of Phantom Pains.- Trigger Mechanisms.- Pathogenesis of Pain Syndromes in the Light of the Generator Mechanism Theory.- Relationship between Peripheral and Central Mechanisms in Causalgia and Neuralgia.- Deafferentation Pain Syndrome.- Certain Peculiarities of the Pain Syndromes in the Light of the Generator Mechanism Theory.- On the Theory of the Generator Mechanisms of Central Pain Syndromes: Evolution of Concepts.- Summary.- 10 - Syndromes of Caudate Nuclei.- Stereotyped Behavior Syndrome.- Catatonia Syndrome.- Parkinson's Syndrome.- Rotation Syndrome.- Chorea-like Hyperkinesis.- Summary.- 11 - Pathologically Prolonged Sleep.- Summary.- 12 - Models of Neurotic and Psychotic States.- Syndromes of Hyperactivity of the Dopamine Apparatus.- Syndromes Induced by GPEEs Created in Hypothalamic Nuclei.- Syndromes which Originate when GPEE is Produced in the Bulbar Dorsal Raphe Nucleus and Other Brain Areas.- Summary.- Basic Therapeutic Principles and Recovery Mechanisms.- 13 - Basic Therapeutic Principles.- Influence on the Determinant Structure.- Influence on the Pathologic System.- Influencing the Pathologic Systems by Activating the Antisystems.- Complex Pathogenetic Therapy.- Combination of Ablative and Stimulative Interventions with Pharmacological Effects.- Metabolic Therapy.- Summary.- 14 - Recovery Mechanisms.- Summary.- In Lieu of a Conclusion.- References.
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Produktdetaljer

ISBN
9780306109829
Publisert
1986-01-31
Utgiver
Vendor
Kluwer Academic / Plenum Publishers
Aldersnivå
P, 06
Språk
Product language
Engelsk
Format
Product format
Innbundet
Antall sider
444

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