This book forms an important part of the current revival of the debate around the category of historical epistemology. The term “historical epistemology” designates a methodology or research program aimed at building a historically informed theory of knowledge and/or a history of science and technology that enhances its epistemological aspects. This book offers an original panorama of the French debate surrounding the emergence and consolidation of the intellectual program of historical epistemology over a period ranging from the end of the 19th century to the second half of the 20th century. The first section of this book sets out to reconstruct sociologically and historically the processes of circulation of ideas - both nationally and internationally - that constituted the conditions of possibility for the emergence of the very idea of historical epistemology in the French intellectual context. The second section aims instead to highlight the main theoretical positions - both epistemological and historiographical - that would make it possible to trace a relative unity of intent among the authors who make up the canon of historical epistemology (in their oppositional relationship to other intellectual trends). Particular attention is also paid to defining a “minor canon” of this tradition, represented by what is known as “mathematical thought”. The third part of the volume focuses instead on reconstructing the anthropological, sociological and political perspectives underlying the methodology employed by authors belonging to historical epistemology. The three parts combined make for a uniquely broad yet focused book that is of interest to historians, philosophers and scientists alike.