This fourth edition of the best-selling textbook, Human Genetics and Genomics, clearly explains the key principles needed by medical and health sciences students, from the basis of molecular genetics, to clinical applications used in the treatment of both rare and common conditions.

Preface vii How to get the best out of your textbook viii PART ONE: BASIC PRINCIPLES OF HUMAN GENETICS 1 1 DNA Structure and Function 3 2 Genetic Variation 20 3 Patterns of Inheritance 38 4 The Human Genome 64 5 Multifactorial Inheritance 87 6 Cell Division and Chromosomes 100 7 Population Genetics 125 8 Cancer Genetics 137 PART TWO: GENETICS AND GENOMICS IN MEDICAL PRACTICE 155 9 Chromosome Translocation 157 10 Molecular Diagnosis 171 11 Newborn Screening 182 12 Developmental Genetics 194 13 Carrier Screening 203 14 Genetic Risk Assessment 213 15 Genetic Testing for Risk of Cancer 222 16 Pharmacogenetics 230 17 Treatment of Genetic Disorders 239 Answers to Review Questions 248 Glossary 253 Index 262

This fourth edition of the best-selling textbook, Human Genetics and Genomics, clearly explains the key principles needed by medical and health sciences students, from the basis of molecular genetics, to clinical applications used in the treatment of both rare and common conditions. A newly expanded Part 1, Basic Principles of Human Genetics, focuses on introducing the reader to key concepts such as Mendelian principles, DNA replication and gene expression.??Part 2, Genetics and Genomics in Medical Practice, uses case scenarios to help you engage with current genetic practice. Now featuring full-color diagrams, Human Genetics and Genomics has been rigorously updated to reflect today's genetics teaching, and includes updated discussion of genetic risk assessment, "single gene" disorders and therapeutics. Key learning features include: Clinical snapshots to help relate science to practice'Hot topics' boxes that focus on the latest developments in testing, assessment and treatment'Ethical issues' boxes to prompt further thought and discussion on the implications of genetic developments'Sources of information' boxes to assist with the practicalities of clinical research and information provisionSelf-assessment review questions in each chapter COMPANION WEBSITE Accompanied by the Wiley E-Text digital edition (included in the price of the book), Human Genetics and Genomics is also fully supported by a suite of online resources at www.korfgenetics.com, including: Factsheets on 100 genetic disorders, ideal for study and exam preparationInteractive Multiple Choice Questions (MCQs) with feedback on all answersLinks to online resources for further studyFigures from the book available as PowerPoint slides, ideal for teaching purposes The perfect companion to the genetics component of both problem-based learning and integrated medical courses, Human Genetics and Genomics presents the ideal balance between the bio-molecular basis of genetics and clinical cases, and provides an invaluable overview for anyone wishing to engage with this fast-moving discipline. Of related interest Medical Genetics at a Glance, 3rd edition - Forthcoming Dorian Pritchard and Bruce Korf, 2013, ISBN 9780470656549 For more information on the complete range of Wiley-Blackwell medical student and junior doctor publishing, please visit: www.wileymedicaleducation.com All content reviewed by students for students Wiley-Blackwell Medical Education books are designed exactly for their intended audience. All of our books are developed in collaboration with students. This means that our books are always published with you, the student, in mind. If you would like to be one of our student reviewers, go to www.reviewmedicalbooks.com to find out more. This new edition is also available as an e-book. For more details, please see www.wiley.com/buy/9780470654477 or scan this QR code: