Biomarkers in Kidney Transplantation: Clinical Aspects and Laboratory Determination provides a focused study on traditional and emerging biomarkers to predict early rejection of kidney transplants supporting appropriate therapeutic interventions. Coverage includes predictive and diagnostic biomarkers for different types of rejections, including biomarkers of acute, chronic/sub chronic rejection or clinical rejection, T-cell mediated rejection, antibody mediated rejection and mixed rejection. Comparisons are provided for broad classification of pharmacokinetic versus pharmacodynamic biomarkers, and differentiation is shown between the susceptibility, diagnostic, predictive, prognostic and monitoring biomarkers. Coverage of the analytical aspects of biomarker measurement, the process of biomarker discovery and their clinical validation addresses both the clinical features of biomarkers as well as the pitfalls of determining such biomarkers in clinical laboratories. By combining all current markers known for kidney transplant in one collection, this easy-to-use reference is perfect for pathologists, clinical pharmacologists, clinical laboratory scientists and all physicians involved in organ transplantation, including immunologists and transplant surgeons.
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1. Organ transplantation: past, present, and future 2. Trends in kidney transplantation 3. Immunobiology in kidney transplantation 4. Immunosuppression in kidney transplantation 5. Challenges in the therapeutic drug monitoring of immunosuppressants 6. Overview of biomarkers in kidney transplantation 7. Biomarkers for ischemia reperfusion injury and delayed graft function 8. Biomarkers of renal transplant rejection: yesterday, today, and tomorrow 9. Biomarkers predicting the response to immunosuppressant therapy 10. Biomarkers of recurrent disease after kidney transplantation 11. Biomarkers of tolerance in renal transplantation 12. Biomarkers for detecting opportunistic infections in renal transplant recipients 13. Biomarkers for detecting nephrotoxicity due to immunosuppressant drugs 14. Biomarkers for drug development in kidney transplantation 15. Commercially available biomarker tests in kidney transplantation 16. The unmet needs, current challenges and future directions for biomarkers in renal transplantation
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Focused study on traditional and emerging biomarkers to predict early rejection of kidney transplant that supports appropriate therapeutic interventions
Includes comprehensive coverage on all available biomarkers to predict organ rejection Provides guidance on how to interpret test results of all available biomarkers Covers possible sources of errors in measuring biomarkers to eliminate issues of interference
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Produktdetaljer

ISBN
9780128240694
Publisert
2025-10-24
Utgiver
Elsevier Science Publishing Co Inc
Vekt
450 gr
Høyde
276 mm
Bredde
216 mm
Aldersnivå
P, 06
Språk
Product language
Engelsk
Format
Product format
Heftet
Antall sider
356

Biografisk notat

Smita Pattanaik received her MBBS from Utkal University, an MD in Pharmacology from PGIMER Chandigarh, DNB in Pharmacology from National Board of Examination New Delhi and DM in Clinical Pharmacology from PGIMER Chandigarh. Her current research focuses on concentrate on clinical pharmacology of immunosuppressant drugs, therapeutic drug monitoring and dose individualization (PK/PD) modeling and pharmacogenomics, clinical research methodology and biostatistics, clinical pharmacology of genitourinary system and bladder cancer chemotherapy. Ashish Sharma is a highly experienced transplant surgeon. He has more than 200 publications in national and international journals. He has been instrumental in starting academic training programs in kidney and pancreas transplant at PGIMER. Under his leadership, the department has been able to establish a pancreas transplant program, donation after cardiac death, along with a comprehensive surveillance and interventional vascular access program. He has been awarded by the Ministry of Health and the Indian Society of Organ Transplant for his exemplary services in transplant.