Lyssaviruses are the etiological agents of rabies, one of the oldest documented and feared maladies in medical history. Yet, despite these academic and practical advances in research, the age-old horror evoked by rabies is still very real, with only four documented human recoveries once symptoms are realized.

List of Contents.- Rationale and Prospects for Rabies Elimination in Developing Countries.- Functional Aspects of Lyssavirus Proteins.- Reproduction of Lyssaviruses: Ultrastructural Composition of Lyssavirus and Functional Aspects of Pathogenesis.- The Molecular Basis for Altered Pathogenicity of Lyssavirus Variants.- Animal Models of Rabies Virus Neurovirulence.- The Pathogenesis of Rabies and Other Lyssaviral Infections: Recent Studies.- Human Rabies: Clinical Aspects, Pathogenesis, and Potential Therapy.- Immunobiology of Lyssaviruses: The Basis for Immunoprotection.- Immunoprotection by Rabies Virus Nucleoprotein.- Current and Future Immunoprophylaxis Against Human Rabies: Reduction of Treatment Failures and Errors.- Production of Human Monoclonal Antibodies Against Rabies Virus.- Bat Lyssaviruses in Europe.- Oral Wildlife Rabies Vaccination Field Trials in Europe, with Recent Emphasis on France.- Oral Rabies Immunization of Wildlife and Dogs: Challenges to the Americas.- The Biology of Southern African Lyssavirus Variants.- Rabies Epidemiology: Some Ecological and Evolutionary Perspectives.- Beyond Pasteur to 2001: Future Trends in Lyssavirus Research?.

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