Navigating Endophytic Research for Next-Generation Therapeutics explores the evolving field of endophytic fungal research and applications in combating diseases, addressing environmental challenges, and in shaping the future of therapeutics. The book starts off with a discussion on the biodiversity and biogeography of endophytic fungal communities and describes the bioprospecting of endophytes for drug discovery. In addition, it covers the therapeutic application of endophytic fungi to treat and manage specific diseases and investigates the innovative use of technologies such as genome editing, genetic engineering for enhanced bioactivity, multi-omics-based exploration, and the use of big data and machine learning in endophytic drug discovery. Featuring contributions from experts across fields like mycology, pharmacology, biotechnology, and environment science, this comprehensive, practical, and insightful resource guides those engaged in endophytic fungal research and its transformative potential in next-generation therapeutics.
Les mer
1. Diversity and Biogeography of Endophytic Fungal Communities 2. Bioprospecting Ethnopharmacological Plants for Endophytic Fungal Drug Discovery 3. Biological Diversity Hotspots: Exploring Endophytic Fungi in Unique Ecosystems 4. Pharmaceutical Applications of Endophytic Fungi: Current Successes and Future Prospects 5. Endophytic Fungi in Anti-cancer Drug Development: Targeting Tumor Microenvironment 6. Neuropharmacology of Endophytic fungal Bioactives: Promising Leads for Brain Disorders 7. Antimicrobial Potential of Endophytic Fungal Compounds: Fighting Drug Resistance 8. Immunomodulatory Properties of Endophytic Fungi: Implications for Therapeutics 9. Antioxidant and Anti-inflammatory Endophytic Fungal Compounds for Chronic Diseases 10. Endophytic Fungi and Metabolic Disorders: From Diabetes to Obesity 11. Endophytic Fungi as Sources of Cardiovascular Drug Leads 12. Commercialization of Endophytic Fungal-Derived Therapeutics: Opportunities and Challenges 13. Clinical Trials and Commercialization of Endophytic Fungal-Derived Therapeutics 14. Endophytic Fungi and Multi-omics Integration: Data-Driven Drug Discovery 15. Endophytic Fungi in Aquatic Environments: Exploring Novel Drug Resources 16. Endophytic Fungi and Age-Related Diseases: Potential for Geriatric Therapeutics 17. Endophytic Fungi and Natural Insecticides: Eco-friendly Alternatives for Pest Control 18. Endophytic Fungal-Derived Antivirals: Expanding the Armamentarium Against Emerging Pathogens 19. Bioprospecting Extremophiles: Endophytic Fungi from Extreme Environments 20. Nanotechnology and Endophytic Fungi: Advancements in Drug Delivery and Targeting 21. Bioinformatics and Omics Tools in Endophytic Fungal Research 22. Genetic Engineering of Endophytic Fungi for Enhanced Bioactivity 23. Metabolomics and Natural Product Profiling of Endophytic Fungi 24. Big Data and Machine Learning in Endophytic Drug Discovery: Accelerating Innovations 25. Endophytic Fungi from Marine Environment and their Bio-Actives, Genome Editing, Endophytic Fungi for Biotransformation
Les mer
Consolidated reference that covers the latest advancements, emerging technologies, and applications of endophytic fungi in various therapeutic areas
Explores diverse research techniques for isolating, culturing, and characterizing endophytic fungi Demonstrates how endophytic fungi have been successfully utilized in drug discovery and therapeutic applications Recognizes the importance of responsible research practices and ethical considerations in bioprospecting and drug development
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Produktdetaljer

ISBN
9780443314841
Publisert
2025-03-26
Utgiver
Elsevier Science Publishing Co Inc
Vekt
450 gr
Høyde
235 mm
Bredde
191 mm
Aldersnivå
P, UP, 06, 05
Språk
Product language
Engelsk
Format
Product format
Heftet
Antall sider
500

Biografisk notat

Dr. Vagish Dwibedi is an academic researcher with over eight years of experience in biotech research and development. He received his PhD from NIPER Mohali and Thapar University in Patiala, India and is currently a Visiting Scientist at the Agriculture Research Organization (ARO) - The Volcani Institute in Rishon Lezhion, Israel. Before joining ARO, he served two years as an Assistant Professor in the Department of Biotechnology at Chandigarh University and was a Research Scientist at Agpharm Bioinnovations LLP. Dr. Dwibedi’s work is directed towards the development of screening platforms for different biological activities such as anti-microbial, antioxidant, anti-cancer, or finding novel molecules that interfere in the mechanism of development of diseases such as Alzheimer's Dementia (AD), Parkinson's disease (PD), Obesity, Anti-gout (arthritis) and Type 2 Diabetes. He has published more than 30 research papers in various national and international journals and has two Indian patents. Dr. Neha Kapoor is a distinguished researcher who earned her PhD from Thapar University, Patiala. She is presently working as Associate Professor in the School of Applied Sciences at Suresh Gyan Vihar University, Jaipur. With an academic and research career spanning over 13 years, she is an expert in microbial biotechnology, molecular biology, and bioinformatics. Her research centers around investigating and characterizing microbial systems that possess the unique ability to emanate groundbreaking therapeutic molecules, specifically tailored to combat prevalent human lifestyle and metabolic diseases viz. cancer, cardiovascular disorders, diabetes, inflammatory and neurological disorders etc. Her outstanding contributions to the field are evidenced by the publication of more than 30 research papers in international and national journals and 4 book chapters. Dr. Lokesh Gambhir is Associate Professor and Dean of Research at Shri Guru Ram Rai University, Dehradun, Uttarakhand. He received his Doctorate degree in radiation biology and immunology from the Bhabha Atomic Research Center (BARC) in Mumbai He is an accomplished academician and researcher with more than 13 years of experience. He is also a recipient of research project grant from DST-SERB SRG (2022), UCB, USERC, Uttarakhand for the probable development of cancer therapeutics from fungal endophytes. Apart from this, Dr. Gambhir has four research projects sponsored by UCB and USERC, Uttarakhand for development of drugs against human disorders. He has published over 25 research papers in peer-reviewed journals and is a recipient of the Young Scientist Award from the Uttarakhand Council for Biotechnology. His research endeavors are centered on the development of innovative drugs and therapies to combat cancer, infectious, and inflammatory diseases. Dr. Swapnil Kajale is currently working as a Postdoctoral Scientist at the Agriculture Research Organization (ARO) - Volcani Institute in Rishon Lezion, Israel. He earned his PhD from Savitribai Phule Pune University in India. Dr. Kajale has over to years of research experience in Microbiology. He has completed several research projects in microbial ecology and microbial taxonomy, barcoding etc. using multi-omics approaches. Before joining the ARO, he was at the National Centre for Microbial Resource (NCMR) which has one of the largest microbial culture collection at DBT-National Centre for Cell Science (NCCS), Pune, India. Here, he was responsible for maintaining the patent deposits in the International Depository Authority (IDA) under the Budapest Treaty. He awarded a ARO-Postdoctoral Fellowship in Israel to conduct the research within the framework of an Israeli Ministry of Agriculture project on antibiotic resistance in agro-environments. He has published 20 research papers in various international journals.