William Clark sets out a well-balanced accoumt of the complexities of his controversial field of medical research. He offers a clear description of how genes work and of the attempts that are being made to isolate and transfer them to new homes... unlikeso many of the popular works of this kind, does not duck complexities or overstate progress.

The Times Higher Education Supplement

In the New Healers, William Clark takes on gene therapy with the same verve and clarity which made its previous books on the immmune system and the biology of the cell such a pleasure.

New Scientist

Human beings have on the order of 100,000 different genes encoding the molecules needed to build and operate the human body; defects in any one of them can lead to disastrous consequences. There are an estimated 4,000 genetic diseases, which can be every bit as devastating as the diseases caused by bacteria or viruses, and in one way they are much worse: we pass them on to our children, generation after generation after generation. The New Healers is the story of the devastation these diseases cause, and the scientific researchers and doctors who struggle to combat them. Science and medicine have provided us with clues to the treatment of a few genetic diseases, although by their very nature they have never been considered curable. But, as William R. Clark shows, that is about to change through one of the most profound revolutions in modern medicine: gene therapy, a branch of the new field of molecular medicine. Clark takes us to the laboratories which have been able to isolate human genes, to make billions of copies of them, and to reintroduce healthy genes into unfortunate individuals who have inherited damaged or functionless genes. He also shows us how this same technology, turned around on itself, can also be used to deliberately introduce "bad" genes to attack and destroy unwanted cells, such as cancer cells or those infected with the AIDS virus. Molecular medicine will be a major part of our lives in the new millennium. The New Healers outlines the powerful and compelling logic behind molecular medicine: that everything we know about molecular biology tells us that it can work, and that it will work. Clark introduces us to the scientists working now to map out the entire human genome, easily the medical equivalent of going to the moon, taking human beings to a completely new level of understanding of our biological selves. Clark also helps us to begin thinking about how we will manage that understanding, and how we will use the information we gain. The New Healers is a clear and compelling introduction to this important new frontier of human medicine, outlining for readers all the basic elements of molecular biology necessary to understand molecular medicine, and illustrating the fascinating stories of those doctors and patients already a part of this exciting future -- a future as full of promise as anything we have witnessed in this past century of remarkable progress.
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An introduction to gene therapy, a branch of molecular medicine which may lead to cures for over four thousand currently incurable genetic diseases including cancer and AIDS. Clark introduces the reader to the elements of molecular biology necessary to understand this new branch of medicine.
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"Every revolution needs a primer. What Paul deKruiff did for the bacteriological revolution in The Microbe Hunters and Lewis Thomas did for the biological revolution in The Lives of a Cell, William Clark has done for the revolution in molecular medicine: He has made a tough new science a pleasure to understand. He makes it clear that molecular medicine, and its subset of gene splicing, constitute the real `alternative medicine' of today; its aim is to find and correct, once and for all, the deepest flaws that lurk in our genes. Clark's book is also a short history of the technical and moral problems that gene therapy has faced. It's a noble story, well told."--Gerald Weissmann, author of Democracy and DNA "Although his subjects have been treated reputably by others, Clark distinguishes himself by dealing with them as though they were topics to be studied for practical purposes.... Molecular medicine is hard to comprehend. Clark explains it clearly and logically, communicating some of the excitement of the researchers and clinicians who study and use it."--Booklist "Bravely and coherently, Clark explains why gene therapy--the subject of much hype and a certain amount of disillusionment--is currently being proposed mainly for clinical trials of the complex diseases cancer and AIDS.... Recommended for academic and public libraries.... His book will help lay readers understand the evolution of medicine from research lab to clinic and will also give them insight into the molecular biology and genetics that are increasingly influencing individual medical decisions."--Library Journal "[Clark's] book will help lay readers understand the evolution of medicine from research lab to clinic and will also give them insight into the molecular biology and genetics that are increasingly influencing individual medical decisions."--Library Journal Noted in Canadian Medical Association Journal ",,,this book is enjoyable reading that is informative and insightful."--Annals of the Royal College of Physicians and Surgeons of Canada "Clark's book, written for nonscientists as well as students new to the field, uses historical narrative to show how we have arrived at the dawn of a new age in medicine."--The Quarterly Review of Biology
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Tells the extraordinary story of gene therapy, the newest frontier of medicine Describes the amazing revolution in modern medicine that may lead to cures for cancer, AIDS, and nearly 4,000 previously incurable genetic diseases Introduces us to the doctors and researchers on the frontier of molecular medicine, isolating and repairing defective genes Covers some of the most important breakthroughs in modern science, from the discovery of DNA to the vast Human Genome Project
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William R. Clark is Professor Emeritus of Immunology at UCLA. An internationally recognized authority on cellular immune responses, he is the author of At War Within: The Double Edged Sword of Immunity and Sex and the Origins of Death.
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Tells the extraordinary story of gene therapy, the newest frontier of medicine Describes the amazing revolution in modern medicine that may lead to cures for cancer, AIDS, and nearly 4,000 previously incurable genetic diseases Introduces us to the doctors and researchers on the frontier of molecular medicine, isolating and repairing defective genes Covers some of the most important breakthroughs in modern science, from the discovery of DNA to the vast Human Genome Project
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Produktdetaljer

ISBN
9780195130843
Publisert
1999
Utgiver
Oxford University Press Inc
Vekt
204 gr
Høyde
201 mm
Bredde
135 mm
Dybde
10 mm
Aldersnivå
G, 01
Språk
Product language
Engelsk
Format
Product format
Heftet
Antall sider
256

Forfatter

Biografisk notat

William R. Clark is Professor Emeritus of Immunology at UCLA. An internationally recognized authority on cellular immune responses, he is the author of At War Within: The Double Edged Sword of Immunity and Sex and the Origins of Death.