Biology of Mycobacterial Lipids covers various topics pertaining to the advancements and current research in the field of mycobacterial lipids, and on the significant progress in lipidomics, in recent times. The chapters present comprehensive, yet systematic cutting-edge research, comprising mycobacterial lipid terminologies, classifications, biosynthetic pathways, tools and techniques, and functional burgeoning. This unique reference book has contributions from pioneer researchers, experts, and eminent veterans from around the globe. It covers ground-breaking work that will bridge the gap between understanding biochemical patterns related to virulence, pathogenesis, and resistance and elucidating new targets for drug design, identifying biomarkers for predicting risk, early diagnosis, and therapeutic outcome.
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1. An overview of mycolic acids: structure-function-classification, biosynthesis, and beyond
2. Lipid biosynthetic pathways as potential drug targets for emerging mycobacterial pathogens
3. Mycobacterial lipids in the host-pathogen interface: roles in pathogenesis and host immune response
4. Lipids and glycolipids as biomarkers of mycobacterial infections
5. Multifaceted roles of mycobacterium cell envelope glycolipids during host cell membrane interactions
6. Conserved mechanisms drive host-lipid access, import, and utilization in Mycobacterium tuberculosis and M. marinum
7. Biological implications of mycobacterial lipids on NKT-cells stimulation
8. The effect of chemically synthetic mycobacterial mycolates on phospholipidome immunomodulation of murine macrophages
9. Polyketide synthases in mycobacterial lipid metabolism
10. Understanding mycobacterial lipid metabolism and employing it as a tool to produce attenuated TB vaccine candidates
11. Deciphering the physiological role of serine enzymes involved in mycobacterial lipid metabolism using activity-based protein profiling
12. Intrabacterial lipid inclusions: overview of an amazing organelle
13. Multiple facets and functions of the toxin mycolactone produced by Mycobacterium ulcerans
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Provides understanding on how mycobacterial lipid biology helps in developing novel therapeutics and devices to combat infection and drug resistance
Covers major biochemical aspects of mycobacterial lipids, nomenclature, structure and classification, and metabolic pathways
Focuses on recent trends and state-of-the-art technology, used in mycobacterial lipids study
Brings together the functional aspects of mycobacterial lipidome, involvement of lipids in cellular network and signaling, its involvement in virulence and resistance, and host factor manipulations
Highlights the discovery of lipid biomarkers, for diagnostic and therapeutic interventions, using mycobacterial lipidomic studies
Presents lipids at the interface of various other biomolecules with integrative omics aspects
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Produktdetaljer
ISBN
9780323919487
Publisert
2022-06-09
Utgiver
Elsevier Science & Technology
Vekt
630 gr
Høyde
235 mm
Bredde
191 mm
Aldersnivå
P, 06
Språk
Product language
Engelsk
Format
Product format
Heftet
Antall sider
314