Targeted Protein Degradation Technologies offers a comprehensive exploration of the field of targeted protein degradation, from its latest scientific advancements to its potential therapeutic applications. This book begins with a foundational introduction to the mechanisms of protein degradation, followed by an in-depth look at both protease-mediated and lysosome-mediated degradation pathways. The text delves into a range of cutting-edge technologies, including PROTAC, AbTAC, molecular glues, hydrophobic tagging, LYTAC, GlueTAC, and AUTAC. It then explores the development of degraders for specific proteins, such as signal transduction receptors, membrane proteins, and transcription factors. This book concludes with a focused discussion on the clinical applications of targeted protein degradation and provides an insight into the future directions for this field.
This book serves as an invaluable resource for researchers and professionals in molecular biology, cell biology, and related disciplines, particularly those involved in protein degradation and the development of novel therapeutic strategies.
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Part 1: Introduction
1. Mechanisms of protein degradation
2. Overview of targeted protein degradation
Part 2: Summary of targeted protein degradation
3. Protease-mediate degradation
4. PROTAC
5. AbTAC
6. Molecular glues
7. Hydrophobic tagging technology
8. Lysosome-mediate degradation
9. LYTACs
10. Bispecific Apt amer Chimera (BIAC)
11. GlueTAC
12. AUTACs
13. ATTECs
14. AUTOTAC
Part 3: Degradation of Proteins of Interest
15. Degraders of signal transduction receptors
16. Degraders of membrane-associated proteins
17. Degraders of cell cycle- and anti-apoptosis-related proteins
18. Degraders of proteins in epigenetic regulation
19. Degraders of proteins involved in transcription nuclear hormone receptors
20. Transcription factor degraders
Part 4: Clinical applications of targeted protein degradation
21. Clinical development of protein degraders
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An introduction to targeted protein degradation, from molecular mechanisms to clinical potential
• Offers a foundational introduction to the mechanisms of protein degradation
• Features a range of targeted protein degradation technologies and covers the latest advances in each area
• Explores the clinical potential of protein degraders in drug discovery
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Produktdetaljer
ISBN
9780443218163
Publisert
2025-07-28
Utgiver
Elsevier Science Publishing Co Inc
Vekt
840 gr
Høyde
235 mm
Bredde
191 mm
Aldersnivå
P, 06
Språk
Product language
Engelsk
Format
Product format
Heftet
Antall sider
402