This book presents the most recent scientific and technological advances in the fields of engineering mathematics and computational science, to strengthen the links in the scientific community. It is a collection of high-quality, peer-reviewed research papers presented at the First International Conference on Mathematical Modeling and Computational Science (ICMMCS 2020), held in Pattaya, Thailand, during 14–15 August 2020. The topics covered in the book are mathematical logic and foundations, numerical analysis, neural networks, fuzzy set theory, coding theory, higher algebra, number theory, graph theory and combinatory, computation in complex networks, calculus, differential educations and integration, application of soft computing, knowledge engineering, machine learning, artificial intelligence, big data and data analytics, high-performance computing, network and device security, and Internet of things (IoT).