Organ transplantation has become more and more feasible with increasing knowledge about immune tolerance and rejection derived from a greater understanding of their humoural, cellular and molecular mechanisms. Early chapters in this volume cover the basic immunology of transplantation and the role of the clinical laboratory in histocompatibility and transplant monitoring. Further chapters review progress and problems in heart and pancreas transplantation, giving special attention to the spectrum of morphological changes in allografts. Reflecting the current high level of interest in intrahepatic bile ducts, the final chapters cover their architectural properties, normal and abnormal development, and review the whole complex of their paucity in infantile cholestatic diseases. An overview of very topical areas of concern in paediatric pathology, this book will be of interest to all those interested in organ transplantation and the developmental biology of the liver.