This book provides higher education students with a comprehensive resource to assist them in their academic persistence in an online course or program. It addresses a wide selection of topics emphasizing a myriad of factors that impact a student’s persistence, and ultimate success, in an online program or course. The book helps students to gain insight into the skills, knowledge, and attributes needed to succeed in the autonomous nature of an online learning environment. Thus, this book helps students to proactively engage in activities to prepare for online learning. Information presented in each chapter is drawn from theory and recent research centered on persistence of online students in higher education. It incorporates hands-on practical activities to promote application of theory and research, and encourages students to demonstrate their knowledge, skills, and abilities through the use of reflective and thought-provoking activities. Hence, this book provides online students with an up-to-date resource they can use to develop an awareness of their readiness and preparedness for online learning. Additionally, this book equips students with information and strategies aimed at helping them to address gaps in their skills and knowledge that may present them with barriers to academic success. The content of this book is aligned with widely used student learning outcomes and objectives of first-year student seminar courses and orientation programs for graduate and undergraduate students enrolled in online programs. Furthermore, it is deliberately organized and structured to support an online student’s academic journey as they navigate the online learning environment. As such, these features make it an ideal book for use by students, instructors, and academic advisors or college and university academic support staff.