This book provides four strategic recommendations for cross-sector, cross-cultural collaborations to effectively and meaningfully address adverse societal challenges. • Monitor external factors to ensure the environment is conducive for sustainable growth of the initiative. • Employ effective leadership and competent staff who should be given early attention. A multicultural team embodies the organizational attributes and intelligence needed to account for variance in behavior within a context. • Provide sufficient funding and marshal sufficient resources to collect data required to inform learning and make thoughtful, nuanced, strategic decisions as the program progresses. • The project’s commitments must be timely and accurately accounted for. Entering collaboration makes one-on-one commitments between members subject to additional commitments that must be accounted for.