This volume presents a study edition of the lectures delivered by Charles Peirce to the Lowell Institute in Boston in the Fall of 1903. These previously unpublished lectures present a comprehensive and revised statement of his work on the methods of science. Offering mature reflection on a lifetime’s thought and work, they represent the culmination of Peirce's research on scientific objectivity. Alongside the 'Cambridge Conferences Lectures' (1898, edited by K. L. Ketner), the 'Harvard Lectures on Pragmatism' (1903, edited by P. A. Turrisi), and the 'The Logic of Interdisciplinarity' (the project of Peirce’s Monist Series 1891-1909, edited by E. Bisanz), the 'Lowell Lectures of 1903' presented here offer significant insights into Peirce’s mature phase as an explorer of objective methods in interdisciplinary science. This collection will appeal to anyone interested in the work of this great thinker, the history of science, and the history of American intellectual life. The 1903 Lowell Lecture Series was Peirce’s last major public lecture.