The proceeding presents best selected papers presented at 6th International Conference on Smart Computing and Informatics (SCI 2024), held at Department of Computer Science and Engineering, Anil Neerukonda Institute of Technology & Sciences (ANITS), Visakhapatnam, India, during 19 – 20 April 2024. It presents advanced and multi-disciplinary research towards the design of smart computing and informatics. The theme is on a broader front focuses on various innovation paradigms in system knowledge, intelligence and sustainability that may be applied to provide realistic solutions to varied problems in society, environment and industries. The scope is also extended towards the deployment of emerging computational and knowledge transfer approaches, optimizing solutions in various disciplines of science, technology and healthcare. The work is published in three volumes.