The cybersecurity landscape is evolving, and so should your curriculum. Fundamentals of Information Systems Security, Fifth Edition helps instructors teach the foundational concepts of IT security while preparing students for the complex challenges of today’s AI-powered threat landscape. This updated edition integrates AI-related risks and operational insights directly into core security topics, providing students with the tools to think critically about emerging threats and ethical use of AI in the classroom and beyond. The Fifth Edition is organized to support seamless instruction, with clearly defined objectives, an intuitive chapter flow, and hands-on cybersecurity Cloud Labs that reinforce key skills through real-world practice scenarios. It aligns with CompTIA Security+ objectives and maps to CAE-CD Knowledge Units, CSEC 2020, and the updated NICE v2.0.0 Framework. From two- and four-year colleges to technical certificate programs, instructors can rely on this resource to engage learners, reinforce academic integrity, and build real-world readiness from day one. Features and Benefits Integrates AI-related risks and threats across foundational cybersecurity principles to reflect today’s threat landscape. Features clearly defined learning objectives and structured chapters to support outcomes-based course design. Aligns with cybersecurity, IT, and AI-related curricula across two-year, four-year, graduate, and workforce programs. Addresses responsible AI use and academic integrity with reflection prompts and instructional support for educators. Maps to CompTIA Security+, CAE-CD Knowledge Units, CSEC 2020, and NICE v2.0.0 to support curriculum alignment. Offers immersive, scenario-based Cloud Labs that reinforce concepts through real-world, hands-on virtual practice. Instructor resources include slides, test bank, sample syllabi, instructor manual, and time-on-task documentation.