This edited volume advances science teaching and learning by engaging with the learning sciences—an interdisciplinary field spanning cognitive science, psychology, neuroscience, and education. It compiles empirically grounded strategies that illuminate how learning unfolds in authentic contexts such as homes, schools, and museums, while leveraging innovative pedagogies and emerging technologies. Topics include design thinking, immersive and inclusive learning, and the role of equity and empowerment in fostering diverse partnerships that enrich understanding across settings. By integrating leadership, technology, and assessment, the volume models competencies and problem-solving skills, highlighting how environments and cognitive factors shape learning. Adopting a learner-centered perspective, it offers comprehensive coverage that promotes effective teaching and meaningful student engagement, making it an essential resource for educators, researchers, and practitioners in the learning sciences.