Blends biology, clinical science, genetics, and molecular biology of the immune system to provide a complete account of our knowledge of immunologyNew features include full-color artwork and design, over 50 new figures, and text that has been completely revised to reflect the very latest referencesIncorporates a variety of pedagogical aids to assist students in the learning process, including chapter outlines, objectives, and summaries, as well as a self-evaluation section
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Immunology, Second Edition carefully blends biology, clinical science, genetics, and molecular biology of the immune system to provide a coherent and complete account of our knowledge of immunology.
Preface ix Note to Reader xi 1. Introduction to the Immune System 1 2. Cells and Organs of the Immune System 27 3. Innate Immunity 61 4. Antigens and Antibodies 105 5. Antigen-Antibody Interactions and Some Experimental Systems 139 6. The Genetics of Antibody Formation and Structure 179 7. The Major Histocompatibility Complex and Development of Immunity 213 8. The T-Cell Receptor Complex: Characterization, Diversification, Costimulatory Molecules, Thymic Selection, and T-Cell Activation 253 9. Cytokines 285 10. Cellular Interactions: Development of Effector Functions and Their Regulation 321 11. Complement 369 12. Hypersensitivities 397 13. Immunologic Tolerance and Autoimmunity 431 14. Transplantation Immunology 461 15. Tumor Immunology 489 16. Immunodeficiencies 529 17. Immunity to Microbes 561 Glossary of Commonly Used Immunologic Terms 611 Appendix: Human Cluster of Differentiation (CD) Molecules 687 Index 703
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A new edition of the comprehensive and accessible introduction to immunology Immunology: Understanding the Immune System, Second Edition has been thoughtfully and meticulously updated to incorporate the many developments that have occurred in the field since publication of the previous edition. In addition to the consolidation, reconstruction, and revision of key material, features completely new to this edition include: three new chapters on innate immunity, immunodeficiencies, and immunity to microbes; more than fifty new figures; coverage of the latest knowledge on signaling pathways, lymphocyte trafficking, mucosal immunity, molecular mechanisms of receptor diversity, the T-lymphocyte immunological synapse, B-lymphocyte subsets, dendritic cell-driving of CD-4+ T-cell subset activities, biology of the CD-4+ T-cell TH17 subset and regulatory T-cell, cross-presentation, mechanisms of tolerance induction, immunoediting and tumor camouflage and the connection between inflammation and cancer development, immunogenetics of primary immunodeficiencies and the immunology of HIV infections and AIDS, and vaccines; and more—all immersed in full-color artwork, design, and user-friendly text. This Second Edition provides a completely up-to-date introduction to immunology through its careful investigation of: Cells and organs of the human systemInnate immunityAntigens and antibodiesAntigen-antibody interactions and some experimental systemsGenetics of antibody formation and structureThe major histocompatibility complex and development of immunityT-cell receptor complexCytokinesCellular interactionsHypersensitivitiesImmunologic tolerance and autoimmunityTransplantation immunologyTumor immunologyImmunodeficienciesImmunity to microbes Successfully blending biology, clinical science, genetics, and molecular biology, this book represents a complete account of our knowledge of immunology. It is complemented with a number of pedagogical aids that assist readers in the learning process, including chapter outlines, objectives, mini-summaries that provide "mental breathers" within the chapter to reassess the material just covered, full-chapter summaries, figures, and a self-evaluation section. The book ends with an extensive glossary and an appendix. It serves as an excellent textbook for courses in the life and medical sciences at the upper-undergraduate and graduate levels and as a reference for practicing scientists and clinical researchers.
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Produktdetaljer

ISBN
9780470081570
Publisert
2009-09-18
Utgave
2. utgave
Utgiver
Vendor
Wiley-Blackwell
Vekt
1960 gr
Høyde
287 mm
Bredde
224 mm
Dybde
43 mm
Aldersnivå
U, 05
Språk
Product language
Engelsk
Format
Product format
Innbundet
Antall sider
744

Forfatter

Biographical note

Klaus Elgert is Professor in the Department of Biological Sciences at Virginia Polytechnic Institute and State University in Blacksburg, Virginia. He has spent almost 32 years teaching immunology to undergraduate and graduate students and has won numerous teaching awards.