Drug resistance is increasing among a variety of human pathogenic microorganisms such as Enterococcus faecium, Staphylococcus aureus, Klebsiella pneumoniae, Acinetobacter baumaniii, Pseudomonas aeruginosa and Enterobacter spp. (currently dubbed the 'ESKAPE' pathogens), and has emerged as one of the most important clinical challenges of this century. Increased general awareness and fear of these pathogens means there is a growing demand for research to tackle the threat of multidrug resistance. Documenting the latest research in the field, this book discusses current and promising activities to discover new antimicrobials in five key areas: molecular genetics and systems microbiology; synthetic, computational chemistry and chemoinformatics; High Throughput Screening (HTS); non-vertebrate model hosts; and light- and nano-based technologies.
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This book documents the latest research, covering current and promising activities in four key areas: computational chemistry and chemoinformatics, High Throughput Screening (HTS), non-vertebrate model hosts and light and nano-based technologies.
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1: Emerging Antimicrobial Drug-discovery Strategies: an Evolving Necessity 2: The Antibiotic Crisis 3: Structure, Genetic Regulation, Physiology and Function of the AcrAB-TolC Efflux Pump of Escherichia coli and Salmonella 4: Small-molecule Efflux Pump Inhibitors from Natural Products as a Potential Source of Antimicrobial Agents 5: Fungal Efflux-mediated Resistance: from Targets to Inhibitors 6: Vacuolar ATPase: a Model Proton Pump for Antifungal Drug Discovery 7: Drug Tolerance, Persister Cells and Drug Discovery 8: Inhibition of Quorum Sensing as a Novel Antimicrobial Strategy 9: Filamentous Temperature-sensitive Mutant Z (FtsZ) Protein as an Antibacterial Target 10: Lysostaphin: a Silver Bullet for Staph 11: Strategies to Identify Modified Ribosomally Synthesized Antimicrobials 12: Quantitative Structure-Activity Relationship-based Discovery of Antimicrobial Peptides Active Against Multidrug-resistant Bacteria 13: Acetyl-CoA Carboxylase as a Target for Antibacterial Development 14: Underexploited Targets in Lipopolysaccharide Biogenesis for the Design of Antibacterials 15: Predicting and Dissecting High-order Molecular Complexity by Information-driven Biomolecular Docking 16: Antifungals and Antifungal Drug Discovery 17: Pathosystematic Studies and the Rational Design of Antifungal Interventions 18: In Vivo High-throughput Antimicrobial Discovery Screens Utilizing Caenorhabditis elegans as an Alternative Host 19: Drosophila melanogaster as a Versatile Model for the Discovery of Drugs Effective against Human Microbe-induced Infection and Pathology 20: Antimicrobial Photosensitizers: Harnessing the Power of Light to Treat Infections 21: Nanoparticle Platforms for Antimicrobial Therapy 22: Antimicrobial Activity of Carbon Nanotubes
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Produktdetaljer
ISBN
9781845939434
Publisert
2012-08-31
Utgiver
Vendor
CABI Publishing
Vekt
980 gr
Høyde
244 mm
Bredde
172 mm
Dybde
25 mm
Aldersnivå
G, 01
Språk
Product language
Engelsk
Format
Product format
Innbundet
Antall sider
376
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