Produktdetaljer
Biografisk notat
David Machin, Division of Clinical Trials and Epidemiological Sciences, National Cancer Centre, Singapore and UK Children's Cancer Study Group, University of Leicester, UK and Institute of General Practice and Primary Care, School of Health and Related Sciences, University of Sheffield, UKMichael J. Campbell, Medical Statistics Group, Institute of General Practice and Primary Care, School of Health and Related Sciences, University of Sheffield, UK
"…a thorough but concise introduction to study design and data analysis." (<i>E-STREAMS</i>, June 2006) <p>"…a very good attempt to discuss various aspects of clinical research…" (<i>Journal of Biopharmaceutical Statistics</i>, July/August 2006)</p> <p>"This is a well researched, well written, thoughtful, and…easy to read primer…a valuable addition to books for research physicians, medical students, and others…" (<i>Doody's Health Services</i>)</p> <p>"…this book is surprisingly refreshing…could be used in any number of situations with equality utility…" (<i>Canadian Journal of Medical Laboratory Science</i>, 2005)</p>
With the emphasis that is now placed on evidence-based medicine, such care and rigour will inevitably impact on these areas with increasing attention turned to the quality of design.
This title describes what principles can be used to structure research effectively allowing for the required degree of accuracy.
Written by two best selling authors, this book includes many examples from medical literature and will be of great value to all groups conducting studies at the interface of clinical and laboratory research.
Preface ix
Chapter 1 What is Evidence? 1
Chapter 2 Measurement, Forms and Questionnaires 18
Chapter 3 Principles of Study Size Calculation 37
Chapter 4 Randomisation 59
Chapter 5 Cross-sectional and Longitudinal Studies 78
Chapter 6 Surveys, Cohort and Case–Control Studies 109
Chapter 7 Clinical Trials–General Issues 139
Chapter 8 Early Clinical Trials 160
Chapter 9 Phase III Trials 188
Chapter 10 Diagnosis 209
Chapter 11 Prognostic Factor Studies 227
References 246
Tables 255
Index 267
Good design is a pre-requisite for successful medical research and The Design of Studies for Medical Research shows just how this can be achieved. The book focuses on how to effectively design studies and covers all key aspects of the process:
- How to take samples
- How to randomise
- Questionnaire and form design
- Sample size determination
- Design of laboratory experiments
- Design of clinical trials
- Design of epidemiological studies
This book is for anyone working in medical research, from the laboratory through to general practice and public health. It will be ideal for anyone embarking upon research for the first time or submitting a research proposal for funding, but is of relevance to all health and allied health professionals
- Includes examples from the medical literature
- Highlights and summarises key concepts
Produktdetaljer
Biografisk notat
David Machin, Division of Clinical Trials and Epidemiological Sciences, National Cancer Centre, Singapore and UK Children's Cancer Study Group, University of Leicester, UK and Institute of General Practice and Primary Care, School of Health and Related Sciences, University of Sheffield, UKMichael J. Campbell, Medical Statistics Group, Institute of General Practice and Primary Care, School of Health and Related Sciences, University of Sheffield, UK