The main focus of this book is on providing students, neurosurgery trainees, certified neurosurgeons and colleagues in neighbouring disciplines essential information on the evolution of the central nervous system (CNS) of craniata and homo. Therefore the book is divided in three parts: Part I is describing the evolution of CNS of craniata (starting 800 million of years ago). Part II is explaining in detail the exceptional position of the human encephalon. Part III is discussing maturity and immaturity of all parts of CNS of craniatas and the consequences concerning further development of brain structure and psychological functions. In all parts anatomical fundamentals are presented in the form of didactic and self-explanatory illustrations.