This book focuses on challenges that have arisen because of trash discharges and their potential causes and provides long-term sustainable solutions. Globally, the COVID-19 pandemic has caused immense devastation, leading to numerous fatalities as well as substantial economic losses and health issues. With the rise in COVID-19 cases, the amount of biomedical waste has multiplied, exposing more people to the epidemic. For developing countries, waste management is already a problem, and the waste generated during this pandemic situation has made things worse. If improper waste management techniques are not changed, the world will face a new crisis that could be referred to as a "garbage crisis." The increased quantity of COVID-19-associated waste (CAW) and their presence in the environment make them more vulnerable, potentially increasing the danger of food chain contamination. A few countries have already started putting emergency plans in place to address the “waste crisis.” Given the paucity of information on the mutational features and potential hosts of this newly discovered COVID-19, there is a pressing need for an effective plan to protect India's ecosystem against further contamination. To handle the current crisis and prevent the anticipated waste disaster, it is imperative to construct a more effective, automated, computerized, and well-modified waste management system during the COVID-19 period.