This book presents the latest research on combination cancer therapy and the transformative role of microRNA (miRNA) modulation in improving treatment precision and outcomes. It explores how miRNAs—key regulators of gene expression—can enhance the efficacy of chemotherapy, radiotherapy, and immunotherapy while reducing toxicity and resistance. With insights into mechanisms, delivery strategies, and clinical applications, the book bridges molecular research and clinical translation. It highlights recent progress in miRNA-based combination therapies, including advances in delivery systems, tumor targeting, and translational trials. A valuable reference for clinicians, oncologists, molecular biologists, and cancer researchers, this work provides a forward-looking perspective on harnessing miRNA therapeutics to shape the next generation of cancer treatment.