In this issue of Clinics in Chest Medicine, guest editors Dr. John P. Reilly brings his considerable expertise to the topic of Sepsis. Leading experts provide in-depth discussions on fluids, vasoactives, and resusitation targets in septic shock; beyond lactate: biomarkers in sepsis; principals of antimicrobial administration in sepsis; steroids in sepsis; pediatric sepsis; immunology of sepsis; and more. Contains 19 relevant, practice-oriented topics, including sepsis-induced brain injury; cardiac dysfunction and arrhythmia management in sepsis; long-term outcomes after sepsis; future therapeutic targets in sepsis; improving sepsis clinical trial design: lessons from COVID-19; and more Provides in-depth clinical reviews on sepsis, offering actionable insights for clinical practice Presents the latest information on this timely, focused topic under the leadership of experienced editors in the field. Authors synthesize and distill the latest research and practice guidelines to create clinically significant, topic-based reviews