Anhedonia is a key symptom (and often risk factor) for various
neuropsychiatric disorders, including depression, schizophrenia,
substance use disorders, post-traumatic stress disorders, and
Parkinson's Disease, among others. Across disorders, anhedonia has
been associated with worse disease course, including poor response to
pharmacological, psychological and neurostimulation treatments as well
as completed suicide. Mounting evidence emerging from preclinical and
translational sciences has clarified that "anhedonia" can be parsed
into partially independent subcomponents, including incentive
motivation, consummatory pleasure, reward learning, and effort-based
decision making, pointing to distinct neurobiological substrates that
could underlie anhedonic phenotypes. Taking an integrative approach
that emphasizes cross-species integration and dimensional
conceptualization of mental illnesses (e.g., Research Domain Criteria
(RDoC)), this book represents the most comprehensive
evaluation,synthesis and integration of theories and empirical
findings focused on anhedonia. Organized across five parts, the
handbook starts with chapters on the history, etiology, and
assessments of anhedonia (Part I), followed by a section on the role
of anhedonia in psychiatric and neurological disorders (Part II).
Using the RDoC Matrix as a guide, Part III presents chapters
synthetizing preclinical and clinical findings on different reward
processing subdomains (e.g., reward responsiveness, reward valuation,
reward learning). Part IV is focused on selected special topics,
including historical and current perspectives on the transdiagnostic
nature and importance of social anhedonia, the role of inflammation in
the pathophysiology of anhedonia, the use of computational modeling to
“dissect” anhedonia and improve its understanding, and links
between anhedonia and suicide. Finally, Part V includes chapters on
pharmacological, psychological and neurostimulation treatments for
anhedonia.
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Produktdetaljer
ISBN
9783031096839
Publisert
2022
Utgiver
Vendor
Springer
Språk
Product language
Engelsk
Format
Product format
Digital bok