Nursing is an evolving profession that requires continued knowledge updates in formulating a foundation for practice. In order to promote patient safety and satisfaction, it is imperative that nurses monitor publications and increase their knowledge base. Each patient is different; each care management situation requires an individualized plan of care. These require the nurse to develop a personal framework for practice that continually develops from this information. This mandates an evolving knowledge base which this edition will supply for nurses who work to deliver care that is research based and protocol driven. This issue of Nursing Clinics will be both timely and relevant as it will combine two clearly important topics for nurses in care management, pathophysiological updates as well as research based protocols that are important to continuity of validated evidence based care delivery. This will give nurses across organizations the opportunity to see care from a perspective of patient wholeness and not truncate care in order to address total components. With care reimbursement dependent on outcomes, it is important for the nurse to see care as a continuum and not finite. This issue will give nurses this perspective.